Skip Nav Destination
Issues
1 April 2010
-
Cover Image
Cover Image
Cultured melanoma cells were treated with colcemid to arrest growth at metaphase, made to swell with a hypotonic solution, fixed with methanol/acetic acid, and dropped on microscope slides to burst them and spread the chromosomes (blue) tipped by telomeres (red) shown in the center area of the cover image (approximately 3000× magnification; courtesy of Brad Stohr and Elizabeth Blackburn). Several nuclei did not burst during slide preparation (also displaying blue chromosomal DNA and red telomeres) and appear adjacent to the spread chromosomes. Chromosomal DNA was stained with 4',6-diamidino-2-phenylindole (DAPI), and telomeres were marked via a fluorescently labeled peptide nucleic-acid probe specific for telomeric DNA repeats. Telomere maintenance (and thus genomic instability) is sustained by the enzyme telomerase in normal cells. Short telomeres are associated with major cancer risk factors including smoking, inflammation, and obesity. Recently, chronic psychological stress, a risk factor for cancer in animal models, also has been shown to take its toll on telomere maintenance in humans. Therefore, the biology of telomeres and telomerase is a potential source of risk and drug-sensitivity markers for integrative, interdisciplinary cancer prevention involving behavioral and basic scientists, epidemiologists, clinical trialists, and biostatisticians. This biology reflects the exciting science of cancer prevention that enables advances in the practice and clinical impact of cancer prevention on several fronts. See articles by Blackburn, Tlsty, and Lippman (beginning on page 394 ) and Blackburn (on page 393 ) for more information. - PDF Icon PDF LinkTable of Contents
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Guest Editorial
Editorial Commentary
Perspectives
Research Articles
Knockout of the Tumor Suppressor Gene Gprc5a in Mice Leads to NF-κB Activation in Airway Epithelium and Promotes Lung Inflammation and Tumorigenesis
Jiong Deng; Junya Fujimoto; Xiao-Feng Ye; Tao-Yan Men; Carolyn S. Van Pelt; Yu-Long Chen; Xiao-Feng Lin; Humam Kadara; Qingguo Tao; Dafna Lotan; Reuben Lotan
The Detection of Chromosomal Aneusomy by Fluorescence In situ Hybridization in Sputum Predicts Lung Cancer Incidence
Marileila Varella-Garcia; Aline P. Schulte; Holly J. Wolf; William J. Feser; Chan Zeng; Sarah Braudrick; Xiang Yin; Fred R. Hirsch; Timothy C. Kennedy; Robert L. Keith; Anna E. Barón; Steven A. Belinsky; York E. Miller; Tim Byers; Wilbur A. Franklin
Nano-Bio-Chip Sensor Platform for Examination of Oral Exfoliative Cytology
Shannon E. Weigum; Pierre N. Floriano; Spencer W. Redding; Chih-Ko Yeh; Stephen D. Westbrook; H. Stan McGuff; Alan Lin; Frank R. Miller; Fred Villarreal; Stephanie D. Rowan; Nadarajah Vigneswaran; Michelle D. Williams; John T. McDevitt
Advertisement
NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck. None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.