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1 March 2009
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Cover Image
Cover Image
The cover displays a near-infrared photographic image produced by a small-animal fluorescence imaging system (Olympus, Tokyo, Japan) of cathepsin expression marked by Prosense in the small bowel of a mouse. Cathepsin proteins are cysteine proteases and have been implicated in cancer pathogenesis. Prosense is a non-fluorescent macromolecule that is activated and becomes fluorescent through cleavage by cathepsins. Activated Prosense shows up in the adenoma (where false-colored red and orange reflect areas of greater near-infrared signal intensity) but not in the surrounding normal mucosa (where false-colored violet and blue reflect areas of less signal). Therefore, cathepsin activity occurred selectively in the adenoma site. Increased expression of cathepsins B and D also occurred in the plasma of adenoma-bearing mice and in mouse adenoma tissue assessed immunohistochemically. See article by Hung et al. (beginning on page 224) for more information. - PDF Icon PDF LinkTable of Contents
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Commentary
Perspective
Review
Research Articles
Effects of Vitamin D and Calcium Supplementation on Markers of Apoptosis in Normal Colon Mucosa: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Veronika Fedirko; Roberd M. Bostick; W. Dana Flanders; Qi Long; Aasma Shaukat; Robin E. Rutherford; Carrie R. Daniel; Vaunita Cohen; Chiranjeev Dash
Comprehensive Proteome Analysis of an Apc Mouse Model Uncovers Proteins Associated with Intestinal Tumorigenesis
Kenneth E. Hung; Vitor Faca; Kenneth Song; David A. Sarracino; Larissa Georgeon Richard; Bryan Krastins; Sara Forrester; Andrew Porter; Alexandra Kunin; Umar Mahmood; Brian B. Haab; Samir M. Hanash; Raju Kucherlapati
Race, Genetic West African Ancestry, and Prostate Cancer Prediction by Prostate-Specific Antigen in Prospectively Screened High-Risk Men
Veda N. Giri; Brian Egleston; Karen Ruth; Robert G. Uzzo; David Y.T. Chen; Mark Buyyounouski; Susan Raysor; Stanley Hooker; Jada Benn Torres; Teniel Ramike; Kathleen Mastalski; Taylor Y. Kim; Rick Kittles
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