Issues
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Cover Image
Cover Image
Identifying biomarkers of colorectal carcinogenesis in normal-appearing rectal biopsies is critical for risk stratification among patients with a history of polyps. Such biomarkers may also be used to evaluate the efficacy of chemopreventive agents. In the study beginning on page 93, Su and colleagues identified COX-2 as the most predictive biomarker for metachronous colorectal polyps. The cover image is adapted from Fig. 2, which shows a spatial quantification of COX-2 expression in normal-appearing rectal biopsies. These findings suggest that measuring COX-2 expression in rectal biopsies is a promising approach to evaluate the efficacy of chemopreventive agents in mechanistic interventional trials, a crucial step before carrying out large-scale randomized trials targeting polyp and cancer outcomes. - PDF Icon PDF LinkTable of Contents
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Highlights from the Literature
Research Brief
Biological Age Acceleration and Colonic Polyps in Persons under Age 50
Understanding the association of accelerated aging and colorectal PNPs presents an opportunity to develop a risk-stratified approach to colorectal cancer screening in young persons.
Research Articles
Metabolic Phenotype and Risk of Obesity-Related Cancers in the Women’s Health Initiative
Recognizing metabolic dysfunction as a significant risk factor for ORCs underscores the importance of preventive measures targeting metabolic health improvement across all BMI categories.
Alcohol Consumption Does not Modify the Polygenic Risk Score–Based Genetic Risk of Breast Cancer in Postmenopausal Women: Atherosclerosis Risk in Communities Study
Although our findings suggest that alcohol drinking does not modify the PRS-based genetic risk of breast cancer among White and Black women with lower alcohol intake, nevertheless, women should consider limiting alcohol consumption as a general cancer prevention strategy, as indicated in dietary guidelines.
Calculating Future 10-Year Breast Cancer Risks in Risk-Adapted Surveillance: A Method Comparison and Application in Clinical Practice
The German Consortium for Hereditary Breast Cancer recommends annual breast imaging for women if their 10-year breast cancer risk is 5% or higher. Women who initially do not meet this risk threshold may do so later. We propose a simple method to determine future risks based on initial risk assessments.
Roles of Necroptosis, Apoptosis, and Inflammation in Colorectal Carcinogenesis: A Longitudinal Human Study
Our findings suggest that COX-2 expression and combined scores of COX-2, TRPM7, and BAX hold promise for predicting the risk of metachronous polyps and could potentially serve as a tool for assessing the effectiveness of chemopreventive agents in preventing colorectal cancer during intervention trials.
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