Issues
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Cover Image
Cover Image
The cover features a rendering of the landscape of a tumor to help illustrate and introduce a special series, PreCancer Atlas Collection: From Biology to Cancer Interception. Understanding precancer is essential for detecting cancer early and intercepting the neoplastic process. To cultivate this understanding, Cancer Prevention Research is publishing a series of invited review articles on the PreCancer Atlas, an initiative modeled after the Cancer Genome Atlas to catalog and sequence molecular events in premalignant lesions. In the first offering, Maresso and the collection editors - Maitra, Hawk and Vilar - describe the series in an introductory commentary on page 365. Next, Rane and colleagues discuss clonal evolution in healthy and premalignant tissues, as well as the implications for early cancer interception, in their review on page 369. Srivastava and colleagues then review the present and future of the precancer atlases on page 379. (Cover Image: Cancer and the Human Tumor Atlas Network, National Cancer Institute (NCI), 2018, This image is in the public domain.) - PDF Icon PDF LinkTable of Contents
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Spotlight
Commentary
Review
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Research Brief
Reallocating Cervical Cancer Preventive Service Spending from Low- to High-Value Clinical Scenarios
Out-of-pocket fees are a barrier to follow-up care after an abnormal cervical cancer screening test. Among commercially insured Virginians, out-of-pocket costs for follow-up services averaged $144/patient; 34% of cervical cancer screenings were classified as low value. Reallocating low-value cervical cancer screening expenditures to enhance coverage for follow-up care can improve screening outcomes.
Research Articles
Cost-effectiveness of p16/Ki-67 Dual-Stained Cytology Reflex Following Co-testing with hrHPV Genotyping for Cervical Cancer Screening
The p16/Ki-67 dual-stained cytology (DS) test was recently approved in the United States as a reflex test for cervical cancer screening following positive high-risk human papillomavirus (hrHPV) test results. Adding DS reflex to hrHPV and cervical cytology co-testing strategies in the United States is expected to be cost-effective per life-year or quality-adjusted life-year gained.
Associations between Physical Activity and Incidence of Cancer among Overweight Adults in Korea: Results from the Health Examinees-G Study
Overall cancer risk is associated with leisure-time physical activity such as duration, intensity, type, and diversity in overweight males, but not in the general population. The decreased risk was most noticeable for colorectal cancer. Our results suggest that physical activity may reduce the risk of cancer among overweight Asian males.
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