Issues
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Cover Image
Cover Image
A safe and effective method to clear human papillomavirus type 16 (HPV16, depicted in the cover image) is crucial to treat patients with HPV16 infection and low-grade cervical disease. In the study starting on page 219, Einstein and colleagues test a targeted immunotherapy utilizing two priming vaccinations administered intramuscularly at one-month intervals. The vaccines consisted of a DNA expressing HPV16 E7 fused to the alarmin Heat Shock 70 protein, followed by a single boost with a recombinant HPV16 L2E7E6 fusion protein as a filterable aggregate. The results showed that vaccines were well tolerated, and 5 of 11 evaluable patients cleared HPV16 by month 6, with 7 of 11 clearing by month 12. This immune-based approach can potentially eliminate HPV and intercept the development of cervical cancer. - PDF Icon PDF LinkTable of Contents
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Highlights from the Literature
Spotlight
Commentary
Review
Research Articles
Prospective Study of Avocado Consumption and Cancer Risk in U.S. Men and Women
The results of this prospective study suggest that avocado consumption may be associated with decreased risk of total and some site-specific cancers in men.
Safety Run-in of Intramuscular pNGVL4a-Sig/E7(detox)/HSP70 DNA and TA-CIN Protein Vaccination as Treatment for HPV16+ ASC-US, ASC-H, or LSIL/CIN1
This safety run-in study cohort suggests that PVX2 immunotherapy is well tolerated in the target population and is sufficiently safe to warrant further clinical testing in a randomized study. The combined vaccines may facilitate higher-than-expected rate of human papillomavirus type 16 viral clearance 6 and 12 months after treatment, although this requires validation.
Trends and Factors Associated with Fecal Occult Blood Test Utilization among Hispanic Adults in Puerto Rico and the United States: BRFSS 2012–2020
Colorectal cancer screening reduces cancer incidence and mortality. All screening modalities, including less invasive FOBT tests, are underutilized, especially in non-White and low-income populations. Evaluation of trends and factors associated with the increase in the use of colorectal cancer screening can inform programs to address the lack of screening among racial minorities.
Determinants of Lung Cancer Screening in a Minnesota Urban Indigenous Community: A Community-Based, Participatory, Action-Oriented Study
Secondary prevention of lung cancer through screening is potentially lifesaving considering that overall survival of lung cancer is 20% at 5 years but curable if detected at an early stage. This work provides insight into culturally tailored approaches to implementing the service in individuals at high risk of the disease.
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