Issues

Research Articles

Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors

Krishna B. Singh; Eun-Ryeong Hahm; Su-Hyeong Kim; Shivendra V. Singh

The present study shows that breast cancer prevention by WA in rats is associated with suppression of fatty acid synthesis.

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Treatment Strategies and Mechanisms Associated with the Prevention of NASH-Associated HCC by a Toll-like Receptor 4 Inhibitor

Suet-Ying Kwan; Alyssa N. Slayden; Aubrey R. Coronado; Rosamaria C. Marquez; Huiqin Chen; Peng Wei; Michelle I. Savage; Lana A. Vornik; Jennifer T. Fox; Shizuko Sei; Dong Liang; Heather L. Stevenson; Gregory K. Wilkerson; Mihai Gagea; Powel H. Brown; Laura Beretta

Means to prevent development of HCC or progression of small adenomas to HCC in patients with NASH are urgently needed to reduce the growing mortality due to HCC. We characterized the chemopreventive effect of oral administration of the TLR4 inhibitor TAK-242 in a model of NASH-associated HCC.

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Opium Use and the Risk of Liver Cancer: A Case–Control Study

Maryam Marzban; Elham Mohebbi; AliAkbar Haghdoost; Mohammad Aryaie; Mohammad Javad Zahedi; Zaher Khazaei; Mohamad Gholizade; Ahmad Naghibzadeh-Tahami

The results of this study indicate that opium use dramatically increased the risk of liver cancer. Because opioids are increasing for medical and non-medical use globally; accordingly, severe health consequences such as liver cancer have to be investigated widely.

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Association between Statins and Incidence of Cancer in Patients with Dyslipidemia Using Large-Scale Health Insurance Claims Data

Ayako Maeda-Minami; Masayuki Takagi; Yasunari Mano; Hideki Ishikawa; Yutaka Matsuyama; Michihiro Mutoh

This study clarified the relationship between statin use and cancer risk in patients with dyslipidemia. Our study will contribute to medicine selection in patients with hypercholesterolemia level.

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Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer

Parijatham S. Thomas; Anisha B. Patel; J. Jack Lee; Diane D. Liu; Mike Hernandez; Miguel Muzzio; Alejandro Contreras; Valerie Sepeda; Carrie Mays; Diane Weber; Lana A. Vornik; Seema A. Khan; Eileen Dimond; Brandy M. Heckman-Stoddard; Marjorie Perloff; Powel H. Brown

Bexarotene is a rexinoid that has been shown to prevent mammary tumors in mouse models but oral dosing has toxicities. This phase I study evaluates topical bexarotene, as a potential chemoprevention agent, for safety and toxicity in high-risk women for breast cancer.

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