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1 January 2022
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Cover Image
Cover Image
Despite recent recognition of the critical role of aryl hydrocarbon receptor (Ahr)-dependent signaling in colon tumor suppression, its role in regulating colonic crypt stemness and cell-cell communication in vivo has not been elucidated. In the study starting on page 17, Yang and colleagues generated a high-quality atlas of colonic intestinal crypts from wild-type (WT) and intestinal-specific Ahr knockout (KO) mice using single-cell transcriptomics and advanced analytical strategies. These single-cell RNA sequencing analyses provide new evidence of the molecular function of Ahr in modulating putative stem cell driver genes, cell potency lineage decisions and cell-cell communication in vivo. The cover image shows the projection of WT and Ahr KO mouse colonocytes onto a two-dimensional t-SNE space colored projection according to their ascribed cell types. - PDF Icon PDF LinkTable of Contents
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ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Commentary
Research Briefs
Research Articles
Reduction in Vaccine HPV Type Infections in a Young Women Group (18–25 Years) Five Years after HPV Vaccine Introduction in Colombia
Alba L. Combita; Viviana Reyes; Devi Puerto; Raúl Murillo; Ricardo Sánchez; Marcela Nuñez; Gustavo A. Hernandez-Suarez; Carolina Wiesner
Monitoring HPV vaccines post-licensure plays an important role in assessing the progress of immunization programs, demonstrating the impact of vaccines on the population, and providing data for policy needs. In Colombia, HPV vaccines showed effectiveness when administered before start of sexual activity, and two doses are sufficient to achieve good protection
Acknowledgment to Reviewers
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