Skip Nav Destination
Issues
1 November 2021
-
Cover Image
Cover Image
Mutations in the adenomatous polyposis coli (APC) gene that activates Wnt/β-catenin signaling and drives the transcription of oncoproteins (e.g., MYC) essential for malignant progression, occur in over 80% of patients with colorectal cancer. Mutations in APC or other members of the Wnt/β-catenin signaling cascade impair β-catenin degradation and promote translocation of β-catenin to the nucleus, where it mediates a proliferative/survival transcriptional program. Novel compounds that inhibit Wnt/β-catenin signaling can block the effect of such mutations and are attractive drug candidates for cancer chemoprevention or therapy. In a publication starting on page 995 of this issue, Lee and colleagues report that a novel phosphodiesterase 10A (PDE10) inhibitor (ADT 061) suppresses the formation of colorectal adenomas in the Apc+/Min-FCCC mouse model, where tumorigenesis is driven by an APC mutation and nuclear accumulation of β-catenin. PDE10 inhibition activates cGMP/PKG signaling and phosphorylates the oncogenic pool of β-catenin, resulting in its degradation and mitigation of proliferative/survival transcription. The cover shows the colocalization of PDE10 (red) and β-catenin (green) in colon adenomas from Apc+/Min-FCCC mice.Close Modal - PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Commentary
Establishing a Primary Care Alliance for Conducting Cancer Prevention Clinical Research at Community Sites
Bernard W. Parker; Barbara L. McAneny; Edith P. Mitchell; Ana María López; Sandra A. Russo; Pamela Maxwell; Leslie G. Ford; Worta McCaskill-Stevens; for the National Cancer Institute PARTNRS Planning Committee
Review
Research Articles
Suppression of Colon Tumorigenesis in Mutant Apc Mice by a Novel PDE10 Inhibitor that Reduces Oncogenic β-Catenin
Kevin J. Lee; Wen-Chi L. Chang; Xi Chen; Jacob Valiyaveettil; Veronica Ramirez-Alcantara; Elaine Gavin; Alla Musiyenko; Luciana Madeira da Silva; Naga S. Annamdevula; Silas J. Leavesley; Antonio Ward; Tyler Mattox; Ashley S. Lindsey; Joel Andrews; Bing Zhu; Charles Wood; Ashleigh Neese; Ashley Nguyen; Kristy Berry; Yulia Maxuitenko; Mary Pat Moyer; Elmar Nurmemmedov; Greg Gorman; Lori Coward; Gang Zhou; Adam B. Keeton; Harry S. Cooper; Margie L. Clapper; Gary A. Piazza
Proton Pump Inhibitor Omeprazole Suppresses Carcinogen-induced Colonic Adenoma Progression to Adenocarcinoma in F344 Rat
Venkateshwar Madka; Gaurav Kumar; Gopal Pathuri; Janani Panneerselvam; Yuting Zhang; Vishal Ganta; Stanley Lightfoot; Ronald Lubet; Chen S. Suen; Vernon E. Steele; Naveena B. Janakiram; Altaf Mohammed; Chinthalapally V. Rao
Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study
C. Sloane Furniss; Matthew B. Yurgelun; Chinedu Ukaegbu; Pamela E. Constantinou; Catherine C. Lafferty; Eliana R. Talcove-Berko; Alison N. Schwartz; Jill E. Stopfer; Meghan Underhill-Blazey; Barbara Kenner; Scott H. Nelson; Sydney Okumura; Sherman Law; Alicia Y. Zhou; Tara B. Coffin; Nicolette J. Rodriguez; Hajime Uno; Allyson J. Ocean; Florencia McAllister; Andrew M. Lowy; Scott M. Lippman; Alison P. Klein; Lisa Madlensky; Gloria M. Petersen; Judy E. Garber; Michael G. Goggins; Anirban Maitra; Sapna Syngal
EUS-based Pancreatic Cancer Surveillance in BRCA1/BRCA2/PALB2/ATM Carriers Without a Family History of Pancreatic Cancer
Bryson W. Katona; Jessica M. Long; Nuzhat A. Ahmad; Sara Attalla; Angela R. Bradbury; Erica L. Carpenter; Dana F. Clark; Gillain Constantino; Koushik K. Das; Susan M. Domchek; Christina Dudzik; Jessica Ebrahimzadeh; Gregory G. Ginsberg; Jordan Heiman; Michael L. Kochman; Kara N. Maxwell; Danielle B. McKenna; Jacquelyn Powers; Payal D. Shah; Kirk J. Wangensteen; Anil K. Rustgi
Weight Loss During Intrauterine Progestin Treatment for Obesity-associated Atypical Hyperplasia and Early-Stage Cancer of The Endometrium
Chloe E. Barr; Neil A.J. Ryan; A.E. Derbyshire; Y. Louise Wan; Michelle L. MacKintosh; Rhona J. McVey; James Bolton; Cheryl Fitzgerald; Dina Awad; Richard J. Slade; Akheel A. Syed; Basil J. Ammori; Emma J. Crosbie
Advertisement