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Issues
1 January 2021
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Cover Image
Cover Image
Nonalcoholic steatohepatitis (NASH) is a severe form of fatty liver disease characterized by inflammation, steatosis, and fibrosis and balloon degeneration from hepatocyte injury. NASH increases the risk for development of cirrhosis and hepatocellular carcinoma (HCC). Currently, there are no FDA-approved agents to reverse hepatic fibrosis and NASH. In this issue, an investigation by Gay and colleagues (starting on page 17) demonstrates a novel approach to preventing HCC by treatment with a cholecystokinin receptor antagonist, proglumide. Treatment of mice with proglumide reversed NASH; lowered hepatic inflammatory cytokines and chemokines; reduced oxidative stress; and prevented HCC. The anti-fibrotic, anti-inflammatory, and anti-proliferative effects of proglumide may provide hope for future studies to reverse hepatic fibrosis and prevent HCC. Proglumide has a broad safety profile in human subjects and could therefore easily be repurposed for prevention of HCC. The cover histological images show peri-portal fibrosis altering the microenvironment in the liver of a mouse with NASH (left panel) and prevention of these histologic changes with proglumide therapy (right panel). - PDF Icon PDF LinkTable of Contents
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ISSN 1940-6207
EISSN 1940-6215
Spotlight
Commentary
Research Brief
Research Articles
Inflammation Modulation by Vitamin D and Calcium in the Morphologically Normal Colorectal Mucosa of Patients with Colorectal Adenoma in a Clinical Trial
David Corley Gibbs; Veronika Fedirko; John A. Baron; Elizabeth L. Barry; W. Dana Flanders; Marjorie L. McCullough; Rami Yacoub; Tapasya Raavi; Robin E. Rutherford; March E. Seabrook; Roberd M. Bostick
Breast Cancer Chemoprevention: Use and Views of Australian Women and Their Clinicians
Courtney Macdonald; Christobel M. Saunders; Louise A. Keogh; Morgan Hunter; Danielle Mazza; Sue-Anne McLachlan; Sandra C. Jones; Stephanie Nesci; Michael L. Friedlander; John L. Hopper; Jon D. Emery; Martha Hickey; Roger L. Milne; Kelly-Anne Phillips; for the Kathleen Cuningham Consortium for Research Into Familial Breast Cancer
Acknowledgment to Reviewers
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