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1 September 2018
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Cover Image
In 2015, the World Health Organization classified the consumption of red meat as probably carcinogenic to humans, mainly for colon cancer. The associated recommendation was to limit the red meat intake to 500 g per week, but not all socio-economic classes are receptive to such nutritional messages. Other means are thus needed to limit cancer risk in all the population. Heme iron is a major actor in the red meat-induced promotion of colon cancer: it catalyses lipid peroxidation and produces cytotoxic and genotoxic aldehydes that could promote carcinogenesis. It was speculated that enrichment of red meat with antioxidant agents using a marinade would decrease meat-associated cancer risk via limitation of the heme induced luminal peroxidation. The cover shows the histological section of an adenoma from the intestin of a female Apc(Min) mice (H&E staining). The adenoma number was reduced in mice given marinated beef meat compared with mice given non-marinated meat. This protection provided by the marinade was associated with the decrease of fecal lipid peroxidation in different cancer animal models and in the stools of human volunteers, without any adverse organoleptic effect. - PDF Icon PDF LinkTable of Contents
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ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Review
PGC-1α as a Biomarker of Physical Activity-Protective Effect on Colorectal Cancer
Fernanda de Souza-Teixeira; Jéssica Alonso-Molero; Carlos Ayán; Laura Vilorio-Marques; Antonio Jose Molina; Carmen González-Donquiles; Veronica Dávila-Batista; Tania Fernández-Villa; Jose Antonio de Paz; Vicente Martín
Research Articles
High Growth Rate of Pancreatic Ductal Adenocarcinoma in CDKN2A-p16-Leiden Mutation Carriers
Isaura S. Ibrahim; Martin N. Wasser; Yinghui Wu; Akin Inderson; Wouter H. de Vos tot Nederveen Cappel; Hans Morreau; Frederik J. Hes; Roeland A. Veenendaal; Hein Putter; Shirin Feshtali; Anneke M. van Mil; Nelleke A. Gruis; Rob A. Tollenaar; Wilma Bergman; Bert A. Bonsing; Hans F.A. Vasen
Breast Hormone Concentrations in Random Fine-Needle Aspirates of Healthy Women Associate with Cytological Atypia and Gene Methylation
Oukseub Lee; Richard E. Heinz; David Ivancic; Miguel Muzzio; Robert T. Chatterton; Carola M. Zalles; Kara Keeney; Belinda Phan; Dachao Liu; Denise Scholtens; Mary Jo Fackler; Vered Stearns; Saraswati Sukumar; Seema A. Khan
Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption
Océane C.B. Martin; Nathalie Naud; Sylviane Taché; Laurent Debrauwer; Sylvie Chevolleau; Jacques Dupuy; Céline Chantelauze; Denis Durand; Estelle Pujos-Guillot; Florence Blas-Y-Estrada; Christine Urbano; Gunter G.C. Kuhnle; Véronique Santé-Lhoutellier; Thierry Sayd; Didier Viala; Adeline Blot; Nathalie Meunier; Pascal Schlich; Didier Attaix; Françoise Guéraud; Valérie Scislowski; Denis E. Corpet; Fabrice H.F. Pierre
Detection and Genotyping of HPV DNA in a Group of Unvaccinated Young Women from Colombia: Baseline Measures Prior to Future Monitoring Program
Devi Puerto; Viviana Reyes; Cristina Lozano; Lina Buitrago; Diego Garcia; Raúl H. Murillo; Nubia Muñoz; Gustavo A. Hernandez; Laura Sanchez; Carolina Wiesner; Alba L. Combita
Retraction
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