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1 October 2018
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Cover Image
Melanoma remains a major challenge in the cancer prevention field, and there are conflicting epidemiologic data on whether chronic aspirin (ASA) use may reduce melanoma risk in humans. Potential anti-cancer effects of ASA may be mediated by its ability to suppress prostaglandin E2 (PGE2) production and activate 5′-adenosine monophosphate-activated protein kinase (AMPK). In the current study, the inhibitory effects of ASA was investigated in a panel of melanoma and transformed melanocyte cell lines and on growth of human tumor xenografts in a preclinical model. The micrograph images show staining (brown) of proliferating tumor cells from mice treated by daily gavage with water (inset) or ASA (cover image). These cells are less prevalent in tumors from the ASA-treated mice. The tumors from ASA-treated animals also expressed lower levels of PGE2 and higher levels of phosphorylated AMPK (not shown). See the article by Kumar et al. (beginning on page 629) for more information.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Review
Research Articles
The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K
Tianshun Zhang; Qiushi Wang; Mangaladoss Fredimoses; Ge Gao; Keke Wang; Hanyong Chen; Ting Wang; Naomi Oi; Tatyana A. Zykova; Kanamata Reddy; Ke Yao; Weiya Ma; Xiaoyu Chang; Mee-Hyun Lee; Moeez Ghani Rathore; Ann M. Bode; Hitoshi Ashida; Scott M. Lippman; Zigang Dong
Aspirin Suppresses PGE2 and Activates AMP Kinase to Inhibit Melanoma Cell Motility, Pigmentation, and Selective Tumor Growth In Vivo
Dileep Kumar; Hafeez Rahman; Ethika Tyagi; Tong Liu; Chelsea Li; Ran Lu; David Lum; Sheri L. Holmen; J. Alan Maschek; James E. Cox; Matthew W. VanBrocklin; Douglas Grossman
Germline and Somatic NF1 Alterations Are Linked to Increased HER2 Expression in Breast Cancer
Xia Wang; Roope A. Kallionpää; Patrick R. Gonzales; Dhananjay A. Chitale; Renee N. Tousignant; Jacob P. Crowley; Zhihua Chen; Sean J. Yoder; Jaishri O. Blakeley; Maria T. Acosta; Bruce R. Korf; Ludwine M. Messiaen; Michael A. Tainsky
Author Choice
Prevention of Lipid Peroxidation–derived Cyclic DNA Adduct and Mutation in High-Fat Diet–induced Hepatocarcinogenesis by Theaphenon E
Heidi Coia; Ning Ma; Yanqi Hou; Marcin D. Dyba; Ying Fu; M. Idalia Cruz; Carlos Benitez; Garrett T. Graham; Justine N. McCutcheon; Yun-Ling Zheng; Bing Sun; Bhaskar V. Kallakury; Junfeng Ma; Hong-Bin Fang; Deborah L. Berry; Vinona Muralidaran; Fung-Lung Chung
Editor’s Note
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