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1 September 2008
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Cover Image
Cover Image
The cover image is a surgical resection specimen of non-neoplastic lung parenchyma (200x magnification). 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) in the lung contributes to the short half-life of prostaglandin E2 in blood, but little was known previously about its cellular location. Immunohistochemical staining showed 15-PGDH expression (strong brown staining) in the cytoplasm of pneumocytes in the non-neoplastic lung parenchyma; this staining/expression was lost in carcinoma tissue (not shown). Reduced expression of 15-PGDH in tumor tissue was associated with an accumulation of multiple bioactive lipids. See article by Hughes et al. beginning on page 241 for more information.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1940-6207
EISSN 1940-6215
Issue Sections
Perspectives
Commentary
Research Articles
NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non–Small Cell Lung Cancer
Duncan Hughes; Taisuke Otani; Peiying Yang; Robert A. Newman; Rhonda K. Yantiss; Nasser K. Altorki; Jeff L. Port; Min Yan; Sanford D. Markowitz; Madhu Mazumdar; Hsin-Hsiung Tai; Kotha Subbaramaiah; Andrew J. Dannenberg
Low-Fat Dietary Pattern and Risk of Benign Proliferative Breast Disease: A Randomized, Controlled Dietary Modification Trial
Thomas E. Rohan; Abdissa Negassa; Bette Caan; Rowan T. Chlebowski; J. David Curb; Mindy Ginsberg; Dorothy S. Lane; Marian L. Neuhouser; James M. Shikany; Sylvia Wassertheil-Smoller; David L. Page
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