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Volume 1, Issue 4

1 September 2008

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Cover Image

Cover Image

The cover image is a surgical resection specimen of non-neoplastic lung parenchyma (200x magnification). 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) in the lung contributes to the short half-life of prostaglandin E₂ in blood, but little was known previously about its cellular location. Immunohistochemical staining showed 15-PGDH expression (strong brown staining) in the cytoplasm of pneumocytes in the non-neoplastic lung parenchyma; this staining/expression was lost in carcinoma tissue (not shown). Reduced expression of 15-PGDH in tumor tissue was associated with an accumulation of multiple bioactive lipids. See article by Hughes et al. beginning on page 241 for more information.
Table of Contents

ISSN 1940-6207

EISSN 1940-6215

Issue Sections

Perspectives
Commentary
Research Articles

Perspectives

Cancer Prevention: Epigenetics Steps Up to the Plate

Jean-Pierre Issa

Extract

View articletitled, Cancer Prevention: Epigenetics Steps Up to the Plate

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Focusing Downstream in Lung Cancer Prevention: 15-Hydroxyprostaglandin Dehydrogenase

Steven M. Dubinett,; Jenny T. Mao; Saswati Hazra

Extract

View articletitled, Focusing Downstream in Lung Cancer Prevention: 15-Hydroxyprostaglandin Dehydrogenase

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Lung Cancer Risk Models Come of Age

John K. Field

Extract

View articletitled, Lung Cancer Risk Models Come of Age

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Commentary

Cancer Risk Assessment and Cancer Prevention: Promises and Challenges

Brian J. Reid

Extract

View articletitled, Cancer Risk Assessment and Cancer Prevention: Promises and Challenges

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Research Articles

Long-term Epigenetic Therapy with Oral Zebularine Has Minimal Side Effects and Prevents Intestinal Tumors in Mice

Christine B. Yoo; Jody C. Chuang; Hyang-Min Byun; Gerda Egger; Allen S. Yang; Louis Dubeau; Tiffany Long; Peter W. Laird; Victor E. Marquez; Peter A. Jones

Abstract

View articletitled, Long-term Epigenetic Therapy with Oral Zebularine Has Minimal Side Effects and Prevents Intestinal Tumors in Mice

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NAD⁺-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non–Small Cell Lung Cancer

Duncan Hughes; Taisuke Otani; Peiying Yang; Robert A. Newman; Rhonda K. Yantiss; Nasser K. Altorki; Jeff L. Port; Min Yan; Sanford D. Markowitz; Madhu Mazumdar; Hsin-Hsiung Tai; Kotha Subbaramaiah; Andrew J. Dannenberg

Abstract

View articletitled, NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non–Small Cell Lung Cancer

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An Expanded Risk Prediction Model for Lung Cancer

Margaret R. Spitz; Carol J. Etzel; Qiong Dong; Christopher I. Amos; Qingyi Wei; Xifeng Wu; Waun Ki Hong

Abstract

View articletitled, An Expanded Risk Prediction Model for Lung Cancer

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Development and Validation of a Lung Cancer Risk Prediction Model for African-Americans

Carol J. Etzel; Sumesh Kachroo; Mei Liu; Anthony D'Amelio; Qiong Dong; Michele L. Cote; Angela S. Wenzlaff; Waun Ki Hong; Anthony J. Greisinger; Ann G. Schwartz; Margaret R. Spitz

Abstract

View articletitled, Development and Validation of a Lung Cancer Risk Prediction Model for African-Americans

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Differential Modulation of Leukotriene B₄ Synthesis and Degradation in Human Bronchoalveolar Lavage Cells by Lipopolysaccharide and Tobacco Smoke

Jenny T. Mao; Donald P. Tashkin; I-Hsien Tsu; Kenneth J. Serio

Abstract

View articletitled, Differential Modulation of Leukotriene B4 Synthesis and Degradation in Human Bronchoalveolar Lavage Cells by Lipopolysaccharide and Tobacco Smoke

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Low-Fat Dietary Pattern and Risk of Benign Proliferative Breast Disease: A Randomized, Controlled Dietary Modification Trial

Thomas E. Rohan; Abdissa Negassa; Bette Caan; Rowan T. Chlebowski; J. David Curb; Mindy Ginsberg; Dorothy S. Lane; Marian L. Neuhouser; James M. Shikany; Sylvia Wassertheil-Smoller; David L. Page

Abstract

View articletitled, Low-Fat Dietary Pattern and Risk of Benign Proliferative Breast Disease: A Randomized, Controlled Dietary Modification Trial

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Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-Inositol Inhibit Tobacco Carcinogen–Induced Lung Adenocarcinoma in Mice

Fekadu Kassie; Ilze Matise; Mesfin Negia; David Lahti; Yunqian Pan; Robyn Scherber; Pramod Upadhyaya; Stephen S. Hecht

Abstract

View articletitled, Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-Inositol Inhibit Tobacco Carcinogen–Induced Lung Adenocarcinoma in Mice

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(−)-Epigallocatechin Gallate Suppresses Azoxymethane-Induced Colonic Premalignant Lesions in Male C57BL/KsJ-db/db Mice

Masahito Shimizu; Yohei Shirakami; Hiroyasu Sakai; Seiji Adachi; Kazuya Hata; Yoshinobu Hirose; Hisashi Tsurumi; Takuji Tanaka; Hisataka Moriwaki

Abstract

View articletitled, (−)-Epigallocatechin Gallate Suppresses Azoxymethane-Induced Colonic Premalignant Lesions in Male C57BL/KsJ-db/db Mice

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