Issues
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Cover Image
Cover Image
Helicobacter pylori infection and cigarette smoking are independent risk factors for gastric cancer. This study by Morris and colleagues starting on page 271 examined how cigarette smoke exposure influences H. pylori gastric colonization and the pathophysiological changes associated with infection. The cover image, adapted from Fig. 3A, displays immunostaining of parietal cells, chief cells, and mucous neck cells—key cell lineages in the gastric corpus. The image illustrates that H. pylori-infected mice exposed to filtered air develop parietal and chief cell atrophy along with mucous neck cell hyperplasia, hallmark features of this infection. However, in H. pylori-infected mice exposed to cigarette smoke, these pathological changes are attenuated. Findings from this study suggest that smokers may be more likely to harbor asymptomatic H. pylori infections, potentially hindering eradication therapy and increasing gastric cancer risk. - PDF Icon PDF LinkTable of Contents
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Highlights from the Literature
Spotlight
Commentary
Research Articles
Chronic Cigarette Smoke Exposure Masks Pathological Features of Helicobacter pylori Infection While Promoting Tumor Initiation
These findings suggest that cigarette smoking suppresses pathophysiological hallmarks of H. pylori infection while accelerating gastric carcinogenesis. Therefore, smokers should receive screening for H. pylori infection to reduce gastric cancer risk.
Solvent Exposure, Genetic Susceptibility, and Risk of Bladder Cancer
Our findings suggest that bladder cancer risk is higher among those exposed to BTX-containing solvents who also harbor common genetic polymorphisms associated with bladder cancer. The joint contribution of genetics and occupational exposures may play an important role in the etiology of bladder cancer.
High-Resolution Anoscopy Referral Rates Adopting Different Anal Cancer Screening Strategies for Men Who Have Sex with Men
Adopting the recent IANS recommendations for anal cancer screening in MSM may be challenging when HRA availability is limited. Estimating the HRA referral rates we would have using 12 different screening algorithms, we highlighted that application of these recommendations implies a careful analysis of the local resource capacity.
Use Patterns of Levonorgestrel-Releasing Intrauterine System among American Women
This study describes the characteristics of American women using the LNG-IUS. Reproductive-age women (especially Hispanic, with lower education, nulliparous, uninsured, and with diabetes) have lower LNG-IUS use odds. These groups may benefit from LNG-IUS use for endometrial cancer primary prevention, conditioned that LNG-IUS use is proven effective in reducing endometrial cancer incidence.
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