This presentation will identify the main lessons learned from the extensive analysis and discussion of the carcinogenicity of outdoor air and describe potential areas for future research. The IARC classification of “outdoor air pollution” and “particulate matter air pollution” as carcinogenic to humans are based on a broad research foundation, but nonetheless there are important gaps to be addressed. For example, research is needed to understand more specifically the components of the air pollution mixture that drive cancer risk, in part to develop useful indicators for control and tracking. Further information is needed on potential determinants of susceptibility to lung cancer caused by air pollution and on the combined effect of smoking and air pollution. Most importantly, this presentation will also cover the implications of the IARC evaluation for public health, including regulatory, societal, and personal actions that, collectively, could improve global public health. Outdoor air pollution now constitutes a cause of cancer to which most people are exposed, and understanding of underlying mechanisms implies that there is no threshold below which there is no risk. Risk assessment will likely play a critical role in considering air quality standards to protect the public from the cancer risk posed by outdoor air pollution.

Citation Format: Jonathan M. Samet. Air pollution and cancer: Implications of IARC's causal classification. [abstract]. In: Proceedings of the Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2014 Sep 27-Oct 1; New Orleans, LA. Philadelphia (PA): AACR; Can Prev Res 2015;8(10 Suppl): Abstract nr CN08-01.