Abstract A34: Association of nut consumption and lung cancer risk in a large population-based case-control study Free

Background: Increased nut consumption has been associated with a reduced risk of major chronic diseases, including type 2 diabetes mellitus, gallstone disease, and colon cancer. However, the association between nut consumption and lung cancer risk is unclear.

Methods: We investigated the association of nut consumption (walnuts, hazelnuts, almonds, or peanuts) with lung cancer risk in the Environment And Genetics in Lung cancer Etiology (EAGLE), a population-based case-control study. Primary lung cancer cases (n= 2101) were enrolled within the Lombardy region of Italy and matched (on gender, residence, and age) to randomly selected controls (n = 2120). Diet was assessed in 1903 cases and 2073 controls. Multivariable odds ratios (ORs) and 95% confidence intervals (CIs) for sex-specific quintiles of intake were calculated using unconditional logistic regression, adjusted for putative confounders including smoking.

Results: Nut consumption was negatively associated with lung cancer risk (OR_Q5-VS-Q1 = 0.72; 95% CI: 0.56-0.92; p-trend =0.014); the association did not change marginally after additional adjustment for consumption of fruits and vegetables (OR_Q5-VS-Q1 = 0.74, 95% CI = 0.58-0.95, p-trend = 0.028).

Conclusion: In summary, dietary nut consumption was associated with reduced risk of lung cancer in EAGLE.

Citation Format: Tram Kim Lam, Dario Consonni, Angela Pesatori, Pier Alberto Bertazzi, Maria Teresa Landi. Association of nut consumption and lung cancer risk in a large population-based case-control study. [abstract]. In: Proceedings of the Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2014 Sep 27-Oct 1; New Orleans, LA. Philadelphia (PA): AACR; Can Prev Res 2015;8(10 Suppl): Abstract nr A34.