We will summarize highlights of new concepts relating to chemoprevention of cancer during a long career of research on this topic. Particular emphasis will be placed on the following topics: carcinogenesis as a chronic disease process, the question of whether asymptomatic people are truly healthy, the use of drugs both singly and in combination for chemoprevention of cancer, tumor cell heterogeneity, the importance of the use of multifunctional drugs for chemoprevention, and the application of drugs developed in cancer studies for diseases other than cancer.

Citation Format: Michael B. Sporn. Chemoprevention of Cancer: Past, Present, and Future. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr PP01-01.