Abstract
Elevated concentrations of arsenic in groundwater pose a public health threat to millions of people worldwide, including severely affected populations in Bangladesh. While arsenic is an established human carcinogen and has been associated with a multitude of health outcomes in epidemiologic studies, a mode of action has yet to be determined for some aspects of arsenic toxicity. In this presentation, we will emphasize the role of recent genetic and molecular epidemiologic investigations of arsenic toxicity. Additionally, we will discuss considerations for the public health impacts of arsenic exposure through drinking water with respect to primary and secondary prevention efforts, including discussion of an on-going chemoprevention trial of selenium and vitamin E supplementation among individuals with manifest arsenic toxicity in Bangladesh.
Citation Format: Maria Argos. Arsenic carcinogenesis. [abstract]. In: Proceedings of the Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2012 Oct 16-19; Anaheim, CA. Philadelphia (PA): AACR; Cancer Prev Res 2012;5(11 Suppl):Abstract nr CN05-02.
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