There are now over 12 million cancer survivors in the United States. Given advances in early detection, supportive care, and therapy, the 5-year overall survival rate for all invasive cancer types exceeds 67%. For many common cancers, such as breast, prostate, testicular, thyroid, bladder, and endometrial cancer, melanoma, and Hodgkin lymphoma, the overall 5-year survival rate exceeds 80%. As the number of long-term survivors has increased, there has been a growing awareness that many will develop health conditions as a direct or an indirect consequence of their cancer therapy or lifestyle, environmental and genetic factors associated with the primary cancer. One of the most serious outcomes experienced by cancer survivors is the diagnosis of a second cancer. The number of patients with multiple primary cancers is growing, with independent malignancies comprising about 16%. Second cancers are a major contributing factor to late mortality following the primary cancer for several high risk groups, including survivors of pediatric or young adult Hodgkin lymphoma. This presentation will describe the current estimates for second cancers, identify high risk populations, and discuss long-term screening strategies and risk-reducing interventions.

Citation Information: Cancer Prev Res 2011;4(10 Suppl):ED02-02.