Abstract
Background: The most of pancreatic ductal adenocarcinomas metastasize even after curative resection. Our goals were to investigate the important factors affecting metastasis and overall survival. Patients and methods: We studied 88 PDACs with R0 resection and evaluated immunohistochemical markers on tissue microarrays to assess the expression levels of the following: EGFR, amphiregulin, VEGF, p-c-met, MMP2, MMP7, MMP9, CXCR3 and CXCR4.
Results: The median OS in patients who had positive vs. negative expression of AREG and MMP9 were 25 vs. 16mo and 24 vs. 13mo respectively (p=0.03, p=0.006). However, the median OS in patients with positive vs. negative expression of MMP2 was 22 vs. 37mo (p=0.04). Adjuvant treatment, postoperative decrement of CA 19–9, angiolymphatic invasion, AREG and MMP2 were independent prognostic factors affecting OS in multivariate analysis. Immunoprofiles revealed that patients with positive expression of p-c-met or VEGF had significantly shorter distant metastasis free survival.
Conclusions: Immunoprofiles revealed the groups with unfavorable tumor biology: negative expression of AREG and positive expression of MMP2. Also, high immunoreactivity of p-c-met or VEGF can be considered as indicators of early distant organ metastasis. These results may give us useful insights in choosing adjuvant treatment modalities and understanding the patterns of PDAC dissemination.
Citation Information: Cancer Prev Res 2011;4(10 Suppl):A112.
RSS Feeds