Abstract CN05-02: Energy balance and cancer at the bench: What's new?

Evidence is strong that a reduction in risk for certain types of cancer is associated with moderate to vigorous physical activity (PA); however, there is limited understanding of the role of type, intensity, duration, and frequency of PA and their mechanisms in accounting for this health benefit. The objective of this presentation is to provide insights from preclinical investigations of PA and breast cancer that inform the general understanding of candidate mechanisms that may account for both the energy dependent and independent effects of PA. Hypotheses about cellular mechanisms will be linked to hypotheses to about systemic effects of PA. Issues considered will include: 1) what contracting muscle releases into circulation or removes from circulation that would directly modulate the carcinogenic process in epithelial cells; 2) whether the effects of muscle contraction on epithelial cell carcinogenesis are exerted in an endocrine, paracrine, autocrine, or intracrine manner; and 3) if the effects of muscle contraction on malignant cells differ from effects on normal or premalignant cells that do not manifest the hallmarks of malignancy.

Citation Information: Cancer Prev Res 2010;3(1 Suppl):CN05-02.