Fumonisins (FB) are mycotoxins produced by the fungus Fusarium verticillioides, which commonly infects corn and other crops worldwide. Exposure to FB is known to have toxic and carcinogenic effects in different animal species, and to express toxicity in cells via the induction of oxidative stress. The aim of the current study was to evaluate the protective effects of the ethanol extract of Aquilegia vulgaris L against the oxidative stress and the genotoxicity using the chromosomal aberrations in somatic cells assay and random amplified polymorphism DNA (RAPDPCR) in FBtreated rats. Sixty mature female Sprague‐Dawley were divided into six treatment groups and treated for 4 weeks as follow: the control group, the group fed fumonisin‐contaminated diet (200 mg/kg diet), the groups treated orally with the extract (5 and 10 mg/kg b.w) and the groups fed fumonisin contaminated diet and treated with the extract at the two doses. The results indicated that animals treated with fumonisin alone disturbs lipid profile in serum, increases Sa/So ratio, induces bone marrow cytotoxicity, increases DNA and RNA in liver accompanied with significant changes in histological picture. The extract alone at the two tested doses did not induce any significant changes in the biochemical or histological picture. The combined treatment showed significant improvements in all tested parameters and histological pictures in the liver tissues. Moreover, this improvement was more pronounced in the group received the high dose of the extract. It could be concluded that the ethanol extract of A. vulgaris induces its protective effect via increase the antioxidant capacity and the inhibition of lipid peroxidation.
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B76.