Introduction: Previous studies showed that BMI decreased serum PSA level. Insulin resistance in obesity is suggested one of reasons. The negative association between BMI and PSA level may be partially due to low testosterone concentration caused by obesity‐related hormonal disturbances (decrease of sex‐hormone binding globulin and increase of aromatase and IR)

Objective: To examine the effect of homeostasis model assessment of insulin resistance (HOMA) index on PSA level after adjusting prostate volume(PV) effect in a screening population.

Design: We performed multivariate linear regression and ANOVA to assess potential influencing factors in a cross‐sectional study of 30‐ to 80‐year‐old Korean men who underwent routine checkups from 2004–2008 (n=3,320).

Main Outcome Measures: Associations between factor variables (BMI, HOMA Index, PV) and PSA level assessed by trends tests by multivariate linear regression and/or ANOVA.

Results: PSA level was negatively associated with BMI before (P for trend <.01) and after (P for trend by quartile <.05 for all) PV stratification, but not associated with HOMA index before (P for trend >.05) and after (P for trend by quartile >.05 for all) PV stratification.

Conclusions: BMI has negative effect on PSA level irrespective of PV stratification, but IR had no association. Hemodilutional effect by obesity may be main cause of BMI's negative association on PSA level.

Citation Information: Cancer Prev Res 2010;3(1 Suppl):A10.