While the total potential of a biological systems response is defined by their genes, and the organism's desired response (to its current status) may be embodied in their transcripts, the metabolome embodies what an organism is actually of doing at a biochemical level. For this reason the metabolomic data may be quite diagnostic of a given disease state, that may or may not be dictated by either the genetic or transcriptomic levels. In this presentation we will discuss an application of metabolomics to define a series of biomarkers. The subsequent explorations of the details of this biomarker have revealed mechanisms that are likely to be significant to the progression of cancer.
Citation Information: Cancer Prev Res 2010;3(12 Suppl):ED01-03.