Abstract
In experimental models of colonic carcinogenesis, aberrant crypt foci (ACF) are the earliest detectable abnormality and precede adenomas. Herein, we wanted to determine the adenoma incidence over a 1-year period after polypectomy. Eighty-nine subjects were recruited from the population of Japanese individuals who underwent polypectomy at Yokohama City University Hospital. All patients had baseline adenomas (> 6mm) removed at year 0 colonoscopy. ACF were defined as lesions in which the crypts were more darkly stained with methylene blue than normal crypts and had larger diameters, often with oval or slit-like lumens and a thicker epithelial lining. A total of 366 ACFs were identified in 89 patients; all had baseline adenomas (> 6mm) removed at the first examination (year 0) colonoscopy and returned for the second (year 1). ACF in the lower rectum were assessed at year 0 and study group were divided into two groups depend on ACF numbers, 0-3 or over 4. All participants were examined in the number and maximum size of adenoma. There was no statistical difference in number and maximum size of ACF at year 0, however, maximum size of adenoma was larger in over 4 group than 0-3 group at year 1. The meaning of the number of ACF is not elucidated; however, the number of ACF may be a predictive factor of relatively large adenoma incidence in the pilot phase study.
Citation Information: Cancer Prev Res 2010;3(12 Suppl):B37.
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