Koetjapic acid is a naturally occurring ichthyotoxic compound which can be isolated from the stem bark of Sandricum keotjape. This is a large tree species that can be found widely in Malaysia and other tropical countries in Southeast Asia. In our studies, we found koetjapic acid to be strongly antiangiogenic causing significant inhibition in endothelial tube formation. The compound inhibited VEGFA expression and caused retardation in cell migration. Keotjapic acid also suppressed the activity of Hif-1a and up regulates TGFβ and NFκB activity. This suggests the potential use of Keotjapic acid to target ailments that is angiogenesis dependent.

Citation Information: Cancer Prev Res 2010;3(12 Suppl):A52.

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2010