ED03-03

The biology of CXC chemokines in cancer has expanded beyond their role in mediating migration of specific subsets of leukocytes. CXC Chemokines have been found to display pleiotropic effects for enhancing immunity to tumor associated antigens, regulating angiogenesis, promoting proliferation/anti-apoptosis of tumor cells; and mediating tumor cell invasion and trafficking in an organ-specific manner that leads to metastases. In this presentation, we will discuss the importance of CXC chemokines in regulating angiogenesis and promoting metastases; and demonstrate why they can be seen as important therapeutic targets for intervention in a variety of cancers.

Citation Information: Cancer Prev Res 2008;1(7 Suppl):ED03-03.

Seventh AACR International Conference on Frontiers in Cancer Prevention Research-- Nov 16-19, 2008; Washington, DC

American Association for Cancer Research
2008