Abstract B63: VKORC1 haplotypes influence serum PIVKAII and transaminases levels in hepatocellular carcinoma patients

VKORC1 haplotypes influence VKORC1 expression and vitamin K-dependent proteins. PIVKAII, named des-γ-carboxy prothrombin, can be used for detecting hepatocellular carcinoma (HCC), and vitamin K deficiency would be associated with low values of serum aspartate transaminase. Whether VKORC1 haplotypes may influence PIVKAII in detecting HCC and serum transaminase?

A number of measures were compared between patients with different VKORC1 haplotype in 228 HCC patients. VKORC1 haplotypes impact on PIVKAII in detecting HCC was detected in 76 HCC patients and 86 controls. Spearman correlation was used to assess the correlation. Youden's index and positive likelihood ratio were used to weigh the proper concentration of PIVKAII for HCC’s prognosis.

In 228 HCC patients, the genotype-frequencies were similar with Chinese common frequencies, while serum PIVKAII and transaminases levels were significantly higher in CC/CT carriers than those in TT carriers. Both in cases and controls, serum PIVKAII levels were significantly higher in SNP2255-CC/CT carriers than those in TT carriers. The estimated optimal cut-off value of PIVKAII for detecting HCC was 2.0ng/ml and 3.0ng/ml in CC/CT carriers and in TT carriers, respectively.

VKORC1 haplotypes could be a complementary to PIVKAII in detecting HCC, and are associated with serum transaminases levels in HCC patients.

Citation Information: Cancer Prev Res 2008;1(7 Suppl):B63.