Radiomodulation by rosemary extract

Dhanraj Soyal, Abhilasha Sharma, Inder Singh and P.K.Goyal+

Radiation and Cancer Biology Laboratory, Department of Zoology,

Rajasthan University, Jaipur 302004

* E-mail; pkgoyal2002@rediffmail.com

Rosemary (Rosmarinus officinalis, Labiateae) is widely used for its antioxidant activities in many parts of the world. The present study investigates the radioprotective and antioxidative potential of rosemary leaves extract (ROE). Swiss albino mice were administered ROE orally once daily for 5 consecutive days, then exposed to a single dose of 3, 6 and 9 Gy of gamma radiation. lipid peroxidation (LPx), Glutathione (GSH), acid phosphatase estimations in liver were carried out. Radiation-induced increases in the levels of lipid peroxidation (LPO) and acid phosphatase were significantly ameliorated by ROE pre-treatment, and radiation-induced depletion in the level of glutathione (GSH) was significantly inhibited by ROE administration. These alterations were found to be dose dependent. The life-span was increased in the ROE treated irradiated mice in comparison with their respective control mice. Radiation-induced deficits in body and organ weight were significantly reduced or prevented in ROE pretreated mice. The protection afforded by ROE may be attributed to the constituents of the rosemary, which include rosmarinic acid, rosmanol, carnosol which appear to play an important role in free radical scavenging and singlet oxygen quenching. The study does not rule out the possibility of a prophylactic potential of ROE against radiation-induced degenerative changes in liver.

Citation Information: Cancer Prev Res 2008;1(7 Suppl):A124.

Seventh AACR International Conference on Frontiers in Cancer Prevention Research-- Nov 16-19, 2008; Washington, DC