Abstract A100: Histological classification of primary lung cancer in relation to age, gender, and types of tobacco smoking.

According to available data the lung cancer remains the leading malignancy amongst males showing a strongest association with smoking. The study was conducted to analyze the histological classification of primary lung cancer in relation to age, gender and types of Tobacco Smoking

The study was conducted on randomly selected 300 patients of 10-90 years age from Ghulab Devi Chest Hospital Lahore. Light microscopy was used for histopathological classification on the sections stained with haematoxylin and eosin. Special (PAS and Alcian blue) stains were used for subclassication. Literature for WHO classification was reviewed.

The primary malignancy of lung was more common in males (male to female ratio was 5.7:1) and in old ages with mean age was 54.17±3.46 years.. Significantly large numbers of patients (70%) were smokers. The trend of smoking is changing in Pakistan from old traditional hukka to cigarette. A strong association of smoking was found between small cell carcinoma (SCC), and squamous cell carcinoma (SQCC), and Large cell carcinoma (LCC), (P<0.02, P< 0.001 and p<0.02 respectively). No significant difference was seen between smokers and non smokers harboring adenocarcinoma (ADC;P>0.05). According to the WHO classification, SQCC (43%) was found to be the commonest histological variant and SCC (22%) was second in the frequency. The frequency of ADC, LCC and others variants was 18%, 11%and 5% respectively.

WHO criteria are the better ways to classify the lung carcinoma with light microscopy and provide a potential widespread and worldwide applicationof this classification system. A strong association of lung cancer was found with age, sex, and all types of smoking and histological variants.

Citation Information: Cancer Prev Res 2008;1(7 Suppl):A100.