On October 20, 2021, I had the privilege of testifying before the House Energy and Commerce Committee, Subcommittee on Health Hearing on Enhancing Public Health: Legislation to Protect Children and Families. This commentary is based on the written testimony I provided to the Subcommittee on issues related to cancer screening and early detection. It highlights the research progress, updated guidelines, and new challenges in this field, emphasizing the importance of screening asymptomatic, at-risk population to detect precancerous lesions or cancer at an early stage.

The data show that cancer screenings save lives and improve outcomes because cancers and pre-cancers can be identified at an earlier stage when physicians can treat them much more effectively. This often results in less invasive treatment, quicker recovery, and a lower cost.


Raymond N. DuBois, MD, PhD, Co-Editor-in-Chief

Cancer organizations such as the AACR publish research that informs the medical community about developments on who, and how, to most effectively screen for different types of cancer. The most influential body is the U.S. Preventive Services Task Force, or USPSTF, which examines the evidence of lower cancer mortality as well as potential risks, such as costs, false negatives and positives, and complications of follow-up procedures to generate screening guidelines. Under the Affordable Care Act, those screening tools graded with an A or a B are required to be covered by insurance without cost to the patient.

As more research is generated, the USPSTF can update its guidelines. This year, the USPSTF broadened eligibility for lung cancer and colon cancer screenings. For lung cancer, after reviewing clinical trial results that found screening a larger segment of the smoking population decreased lung cancer deaths by 24% after 10 years, the USPSTF expanded screening eligibility to smokers as young as 50 who smoked a pack a day for 20 years, nearly doubling the number of individuals who can now be screened at no cost. Previously, only older Americans who smoked a pack a day for 30 years were eligible. These new guidelines are especially beneficial for women and African Americans, who tend to smoke fewer cigarettes than White men yet still have a high risk of developing lung cancer.

The USPSTF also reduced the age recommendations for colonoscopies from 50 to 45, after reviewing evidence of an increase in colon cancer diagnoses among middle-aged Americans.

Effective screening is much better than no screening. However, that does not mean that screening for all cancers without a scientific basis to do so is in the public interest. Overscreening can be cost prohibitive and comes with side effects including radiation exposure and other complications.

The USPSTF has to balance the evidence and the risk benefits. Policymakers should be mindful of USPSTF recommendations and evolving science, as well as other items that should be considered. For lung cancer, for example, the USPSTF recommends screening based on smoking history and age, but does not take into account whether a person grew up in a home with smokers and may have had substantial exposures to second-hand smoke, or increased risk due to occupation or environmental factors. Colon cancer screenings do not take into account the growing evidence that younger obese Americans are being diagnosed with colon cancer at an increasing rate. Mammograms have a high false-positive rate which can lead to unnecessary biopsies and added stress, but a recommendation to start mammograms for women at age 50 will leave many younger women vulnerable for breast cancer that could spread before it would have been detected.

I'd encourage Congress to consider the impact on the individual, especially those at a much higher risk, rather than on the broader population. When designing screening criteria, Congress and the USPSTF should consider heightened cancer risk factors among underserved populations, such as occupation, environmental exposure, and lifestyle factors. Simple age-based criteria contribute to inequities experienced by underserved communities and demographics underrepresented in screening trials. We need to ensure that all racial and ethnic groups and socioeconomic classes have the knowledge to make informed decisions as well as access to evidence-based screening and, importantly, affordable follow-up for positive screens.

In South Carolina, the incidence of breast cancer in Black women is lower than in White women, but their death rate is higher because many Black women have longer delays before they get screened and treated, potentially due to lack of access to health services, mistrust in the health care system, and diagnostic failure.

The mortality rate of prostate cancer in Black men is much worse than White men, and while there could be genetic influences, it is most likely due to lack of access to specialty care and health facilities. These disparities highlight a real and growing threat to public health.

Screening and treatment outcome disparities are areas in which the medical research community must improve. Medicaid/medicare expansion would play a significant role in reducing these health disparities, and the scientific research community must continue to study the most successful methods for cancer screening, particularly for hard to detect cancers such as pancreatic, ovarian, and brain cancers, which currently lack any screening option.

The medical community can also bring new tools to at-risk communities. At the MUSC Hollings Cancer Center (Charleston, SC), we are working to reduce the cancer burden in the I-95 Corridor region. This area, stretching from Georgia to North Carolina, is largely rural and economically disadvantaged, and the majority of the population are in older minority communities. If you look at a map of cancer deaths in South Carolina, it looks like a heatmap of this region lighting up.

Hollings Cancer Center has established Mobile Health Units that travel to underserved areas and work with community health centers, churches, community centers, and employers to bring cancer screening to the people who need it the most.

In addition to advances in healthcare delivery, thanks to congressional investment in basic and translational research, we are at an exciting time in cancer screening. Several academic institutions and industry are making progress on a pan-cancer blood test that would detect certain cancers with very high sensitivity. Cancer in your body sheds a DNA signature into the blood, and these emerging blood tests can detect whether cancer is present and what type of cells the DNA came from. Once validated and proven, these less invasive tests could greatly expand access while reducing costs.

Before I conclude, it's important to mention that we are still not yet at pre-pandemic levels for cancer screening. The NCI estimates that due to COVID-19 delaying cancer screenings, as many as 10,000 additional Americans could die of breast and colon cancer alone in the coming decade. As the scientific community works to improve cancer screening, it is imperative that individuals still maintain recommended screenings from their health providers. The earlier we can detect cancers, the better chance a patient has for living a longer, healthier life.

*A recording of the hearing can be viewed at https://energycommerce.house.gov/committee-activity/hearings/hearing-on-enhancing-public-health-legislation-to-protect-children-and).

No disclosures were reported.