Breast cancer screening (by Project Pink Blue via Wikimedia Commons)

A recent study analyzed the incidence and proportion of interval cancer (IntCa-diagnosis between interval of screening rounds) and screen-detected cancer (ScrCa), stratified by age and estrogen receptor (ER) status. This cohort study followed 527,144 women from Stockholm, Sweden from January 1989 to March 2020. During this time, a total of 29,049 women (5.5%) were diagnosed with breast cancer, of whom 10,631 (2.0%) had ScrCa and 4,369 (0.8%) had IntCa. The proportion of IntCa in screened patients with breast cancer was around 30%, which decreased with older age. Factors associated with an increased risk of IntCa included older age at first childbirth, higher education, use of hormone replacement therapy, and higher mammographic density. Women with IntCa were more likely to have ER–negative cancers (22%) than those with ScrCa (11%). Notably, a family history of ER-negative breast cancer was associated with a...

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