Polygenic risk scores for screening (from Centers for Disease Control and Prevention)

Using UK metrics, Huntley et al. conducted a modeling analysis on the performance of polygenic risk score (PRS) tools and PRS-stratified cancer screening. They estimated the potential annual numbers of cancer cases detected and deaths averted for eight different cancers. The results suggested that, under favorable assumptions, hypothetical PRS-stratified screening programs could modestly improve efficiency for three cancer types. Specifically, they could reduce maximum number of annual deaths from 102 to 80 for breast cancer, 188 to 155 for prostate cancer, and 158 to 95 for colorectal cancer. However, UK-specific cluster-randomized trials are required to evaluate the real-world clinical impact, costs, and potential harm of PRS stratification.

Huntley C, … Turnbull C. Lancet Oncol. 2023 Jun;24(6): 658-668.

Illustration of deep learning (by OpenClipart via FreeSVG)

Pancreatic cancer is often diagnosed too late to achieve good clinical outcomes,...

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