We appreciated the letter by Koulaouzidis and colleagues, which highlights the need for further studies to understand the mechanistic basis for aspirin's effect on colorectal cancer. Alongside their summary of our work (1) in the context of prior studies, they suggest that the effect of aspirin on gut microbiota should be examined. We agree that this is a high priority. As a rationale, they highlight research that shows aspirin appears to alter the gut microbiome to promote bacteria that are anti-inflammatory, thereby reducing colorectal cancer risk (2). We would further add that preclinical studies identify specific microbes that promote a proinflammatory environment, leading to induction of the enzymes that synthesize oncogenic prostaglandins which are inhibited by aspirin. Our group has also demonstrated that aspirin significantly inhibits tumorigenesis in ApcMin/+ mice inoculated with F. nucleatum and adenomas in aspirin users have significantly less Fusobacterium compared with...
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1 October 2022
Letters to the Editor|
October 04 2022
Aspirin, Risk of Colorectal Cancer, & Genetic Risk—Reply Available to Purchase
Andrew Bakshi
;
Andrew Bakshi
1Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
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Andrew T. Chan
Andrew T. Chan
*
2Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts.
3Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts.
*Corresponding Author: Andrew T. Chan, Clinical and Translational Epidemiology Unit, Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114. Phone: 617-643-0112; E-mail: [email protected]
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*Corresponding Author: Andrew T. Chan, Clinical and Translational Epidemiology Unit, Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114. Phone: 617-643-0112; E-mail: [email protected]
Cancer Prev Res 2022;15:703–4
Received:
May 16 2022
Revision Received:
June 16 2022
Accepted:
June 17 2022
Online ISSN: 1940-6215
Print ISSN: 1940-6207
©2022 American Association for Cancer Research
2022
American Association for Cancer Research
Cancer Prev Res (Phila) (2022) 15 (10): 703–704.
Article history
Received:
May 16 2022
Revision Received:
June 16 2022
Accepted:
June 17 2022
Related Content
A commentary has been published:
Aspirin, Risk of Colorectal Cancer, & Genetic Risk—Letter
Citation
Andrew Bakshi, Andrew T. Chan; Aspirin, Risk of Colorectal Cancer, & Genetic Risk—Reply. Cancer Prev Res (Phila) 1 October 2022; 15 (10): 703–704. https://doi.org/10.1158/1940-6207.CAPR-22-0235
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