Spatial Single-Cell Atlas of Lung Adenocarcinoma (Art work from Cancer Discovery)

The development and progression of early-stage lung adenocarcinoma (LUAD) is associated with marked alterations in the surrounding tissue, including changes in seemingly healthy cells. Sinjab et al. used single-cell RNA-seq to analyze five LUAD specimens as well as histologically normal cells from 14 specific locations relative to those tumors, generating detailed molecular maps of the tumor microenvironment. They observe considerable intratumoral heterogeneity, with LUAD specimens harboring normal cells and malignancy-associated alterations observed within non-tumor sites, providing new insights into tumor evolution. These profiles also showed how the immunological environment surrounding LUAD facilitates progression, revealing potential opportunities to develop optimized interventions for early-stage disease.

Sinjab A, … Kadara H. Cancer Discov. 2021 Oct;11:2506–23.

Barrett's mucosa (by Patho via Wikimedia Commons)

The metaplastic condition known as Barrett's esophagus (BE) has been identified as a potential precursor to esophageal...

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