Islam and colleagues report that sildenafil suppresses inflammation-driven colorectal cancer in mice (1). Intestinal cyclic guanosine monophosphate (cGMP) signaling regulates epithelial homeostasis and has been implicated in the suppression of colitis and colon cancer. In their study, Islam and colleagues demonstrated that the cGMP-elevating ability of the phosphodiesterase-5 (PDE5) inhibitor sildenafil can prevent cancer in the azoxymethane/dextran sulfate sodium inflammation-driven colorectal cancer mouse model.

Here, we use data from The Cancer Genome Atlas (TCGA) to assess survival of colon cancer patients with and without mutations of the PDE5A gene.

We assessed the association between PDE5A and colon cancer overall survival using the GDC TCGA Colon Cancer (COAD) cohort in TCGA database. To access and analyze the data, we used the UCSC Xena browser (https://xenabrowser.net). Survival data of the mutant and unmutated PDE5A subgroups were extracted for analysis and generation of Kaplan–Meier curves for overall survival.

Data...

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