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Stephanie K. Dougan
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Journal Articles

Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor That Unleashes PD-1 Checkpoint and CAR T-Cell Immunotherapies

Open Access
Michael Wichroski, Si-Qi Liu, Lauren M. Zasadil, Joseph L. Benci, Patrick C. Gedeon, Kendall J. Condon, Suhasini Joshi, Shana Posy, Patrick Carlson, Alison Maier, Jiao Shen, Rakeeb Kureshi, Yuka Amako, Tai Wang, Ryan L. Powles, Yanyun Li, Tho Lai, Igor Katsyv, Hongchen Qiu, Huilin Qi, Jessica Wong, Dandan Zhao, Dana Banas, Joelle Onorato, Gregory Locke, Xueer Chen, Wen-Chi Chou, Erica Cook, Abigail E. Witt, Christopher M. Barbieri, Hong Zhang, Jonathan B. Olsen, Alba Font-Tello, Eugene Drokhlyansky, Denise C. Grünenfelder, Louis Chupak, Tyler A. Longmire, Jon C. Jones, Travis J. Hollmann, David G. Kugler, John N. Feder, Raphael Bueno, John Wain, Pallavur Sivakumar, Yu Liu, Stephanie K. Dougan, Cloud P. Paweletz, David A. Barbie, Emma Lees
Journal: Cancer Immunology Research
Cancer Immunol Res (2025)
https://doi.org/10.1158/2326-6066.CIR-25-0156
Published: 12 June 2025
View article titled, Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor That Unleashes PD-1 Checkpoint and CAR T-Cell Immunotherapies
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Includes: Supplementary data
Journal Articles

Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor

Open Access
Paul E. Oberstein, Andressa Dias Costa, Emily A. Kawaler, Victoire Cardot-Ruffino, Osama E. Rahma, Nina Beri, Harshabad Singh, Thomas A. Abrams, Leah H. Biller, James M. Cleary, Peter Enzinger, Brandon M. Huffman, Nadine J. McCleary, Kimberly J. Perez, Douglas A. Rubinson, Benjamin L. Schlechter, Rishi Surana, Matthew B. Yurgelun, S. Jennifer Wang, Joshua Remland, Lauren K. Brais, Naima Bollenrucher, Eugena Chang, Lestat R. Ali, Patrick J. Lenehan, Igor Dolgalev, Gregor Werba, Cibelle Lima, C. Elizabeth Keheler, Keri M. Sullivan, Michael Dougan, Cristina Hajdu, Maya Dajee, Marc R. Pelletier, Saloney Nazeer, Matthew Squires, Dafna Bar-Sagi, Brian M. Wolpin, Jonathan A. Nowak, Diane M. Simeone, Stephanie K. Dougan
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (9): 1221–1235.
https://doi.org/10.1158/2326-6066.CIR-23-1073
Published: 03 September 2024
View article titled, Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor
Open the PDF for Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor in another window
Includes: Supplementary data
Journal Articles

TGFβ: Protecting PD-1 from mRNA Decay

Available to Purchase
Stephanie K. Dougan
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (12): 1464.
https://doi.org/10.1158/2326-6066.CIR-20-0881
Published: 01 December 2020
View article titled, TGFβ: Protecting PD-1 from mRNA Decay
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Journal Articles

Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell–Effector Responses

Free
Eleanor Clancy-Thompson, Christine A. Devlin, Paul M. Tyler, Mariah M. Servos, Lestat R. Ali, Katherine S. Ventre, M. Aladdin Bhuiyan, Patrick T. Bruck, Michael E. Birnbaum, Stephanie K. Dougan
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (12): 1524–1536.
https://doi.org/10.1158/2326-6066.CIR-18-0348
Published: 03 December 2018
View article titled, Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell–Effector Responses
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Includes: Supplementary data
Journal Articles

Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs

Free
Michael Dougan, Jessica R. Ingram, Hee-Jin Jeong, Munir M. Mosaheb, Patrick T. Bruck, Lestat Ali, Novalia Pishesha, Olga Blomberg, Paul M. Tyler, Mariah M. Servos, Mohammad Rashidian, Quang-De Nguyen, Ulrich H. von Andrian, Hidde L. Ploegh, Stephanie K. Dougan
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (4): 389–401.
https://doi.org/10.1158/2326-6066.CIR-17-0495
Published: 01 April 2018
View article titled, Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs
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Includes: Supplementary data
Journal Articles

IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells

Free
Eleanor Clancy-Thompson, Lestat Ali, Patrick T. Bruck, Mark A. Exley, Richard S. Blumberg, Glenn Dranoff, Michael Dougan, Stephanie K. Dougan
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (1): 25–35.
https://doi.org/10.1158/2326-6066.CIR-17-0490
Published: 02 January 2018
View article titled, IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells
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Includes: Supplementary data
Journal Articles

Abstract B112: Targeting immunotherapy to the tumor microenvironment using anti-PDL1 VHH

Free
Michael Dougan, Jessica Ingram, Hidde Ploegh, Stephanie K. Dougan
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): B112.
https://doi.org/10.1158/2326-6066.IMM2016-B112
Published: 31 October 2016
View article titled, Abstract B112: Targeting immunotherapy to the tumor microenvironment using anti-PDL1 VHH
Journal Articles

Abstract A067: Quality of initial activation of CD8 T cells specific for TRP1 determines long-term antitumor immunity

Free
Paul Tyler, Mariah Servos, Stephanie K. Dougan
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1_Supplement): A067.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR15-A067
Published: 03 January 2016
View article titled, Abstract A067: Quality of initial activation of CD8 T cells specific for TRP1 determines long-term antitumor immunity
Journal Articles

Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity

Free
Stephanie K. Dougan, Michael Dougan, Jun Kim, Jacob A. Turner, Souichi Ogata, Hyun-Il Cho, Rudolf Jaenisch, Esteban Celis, Hidde L. Ploegh
Journal: Cancer Immunology Research
Cancer Immunol Res (2013) 1 (2): 99–111.
https://doi.org/10.1158/2326-6066.CIR-13-0047
Published: 07 August 2013
View article titled, Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity
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