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Sadna Budhu
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Journal Articles

Abstract B056: Thrombospondin-1:CD47 signaling contributes to the development of T cell exhaustion in cancer

Free
Chien-Huan Weng, Anais Assouvie, Lauren Dong, Jean-Christophe Beltra, Sadna Budhu, Levi Mangarin, Yacine Marouf, Lucia Morgado-Palacin, Cailian Liu, Sébastien Monette, Jonathan Khan, Isabell Schulze, Dmitriy Zamarin, Linda Hamadene, Fadi Samaan, Daniel Hirschhorn, Stephane Pourpe, David Schroder, Roberta Zappasodi, Pamela Holland, Niroshana Anandasabapathy, John Wherry, Jedd D Wolchok, Taha Merghoub
Journal: Cancer Immunology Research
Cancer Immunol Res (2025) 13 (2_Supplement): B056.
https://doi.org/10.1158/2326-6074.IO2025-B056
Published: 23 February 2025
View articletitled, Abstract B056: Thrombospondin-1:CD47 signaling contributes to the development of T cell exhaustion in cancer
Journal Articles

Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models

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Lauren Dong, Hyejin Choi, Sadna Budhu, Isabell Schulze, Svena Verma, Levi M. Mangarin, Valeria Estrada Nevarro, Nezar Mehanna, Jonathan F. Khan, Divya Venkatesh, Daniel Thach, Neal Rosen, Jedd D. Wolchok, Taha Merghoub
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (10): 1392–1408.
https://doi.org/10.1158/2326-6066.CIR-23-0729
Published: 01 October 2024
View articletitled, Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models
Open the PDF for Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models in another window
Includes: Supplementary data
Journal Articles

Abstract PR05: Blockade of AHR activation by IDO/TDO-derived kynurenine restricts cancer immune suppression

Free
Luis F. Campesato, Sadna Budhu, Mathieu Gigoux, Jeremy Tchaicha, Stephane Pourpe, Cailian Liu, Dmitriy Zamarin, Mark G. Manfredi, Karen McGovern, Jedd D. Wolchok, Taha Merghoub
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (4_Supplement): PR05.
https://doi.org/10.1158/2326-6074.TUMIMM18-PR05
Published: 01 April 2020
View articletitled, Abstract PR05: Blockade of AHR activation by IDO/TDO-derived kynurenine restricts cancer immune suppression
Journal Articles

Abstract PR01: Mechanistic rationale to combine GITR agonism with PD-1 blockade in cancer patients

Free
Roberta Zappasodi, Cynthia Sirard, Yanyun Li, Sadna Budhu, Moshen Abu-Akeel, Cailian Liu, Xia Yang, Hong Zhong, Walter Newman, Jinjin Qi, Phillip Wong, David Schaer, Henry Koon, Vamsidhar Velcheti, Michael Postow, Margaret K Callahan, Jedd D. Wolchok, Taha D. Merghoub
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): PR01.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-PR01
Published: 01 February 2019
View articletitled, Abstract PR01: Mechanistic rationale to combine GITR agonism with PD-1 blockade in cancer patients
Journal Articles

Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells

Free
Elliott J. Brea, Claire Y. Oh, Eusebio Manchado, Sadna Budhu, Ron S. Gejman, George Mo, Patrizia Mondello, James E. Han, Casey A. Jarvis, David Ulmert, Qing Xiang, Aaron Y. Chang, Ralph J. Garippa, Taha Merghoub, Jedd D. Wolchok, Neal Rosen, Scott W. Lowe, David A. Scheinberg
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11): 936–947.
https://doi.org/10.1158/2326-6066.CIR-16-0177
Published: 31 October 2016
View articletitled, Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells
Open the PDF for Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract B183: Treg inhibition by anti-GITR therapy evokes therapeutic antitumor responses selectively in the context of a pro-inflammatory tumor microenvironment

Free
Roberta Zappasodi, Sadna Budhu, Cailian Liu, Kyle Draleau, David Schaer, Hong Zhong, Xia Yang, Taha Merghoub, Jedd D. Wolchok
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1_Supplement): B183.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR15-B183
Published: 03 January 2016
View articletitled, Abstract B183: Treg inhibition by anti-GITR therapy evokes therapeutic antitumor responses selectively in the context of a pro-inflammatory tumor microenvironment
Journal Articles

Combination of Alphavirus Replicon Particle–Based Vaccination with Immunomodulatory Antibodies: Therapeutic Activity in the B16 Melanoma Mouse Model and Immune Correlates

Free
Francesca Avogadri, Roberta Zappasodi, Arvin Yang, Sadna Budhu, Nicole Malandro, Daniel Hirschhorn-Cymerman, Shakuntala Tiwari, Maureen F. Maughan, Robert Olmsted, Jedd D. Wolchok, Taha Merghoub
Journal: Cancer Immunology Research
Cancer Immunol Res (2014) 2 (5): 448–458.
https://doi.org/10.1158/2326-6066.CIR-13-0220
Published: 01 May 2014
View articletitled, Combination of Alphavirus Replicon Particle–Based Vaccination with Immunomodulatory Antibodies: Therapeutic Activity in the B16 Melanoma Mouse Model and Immune Correlates
Open the PDF for Combination of Alphavirus Replicon Particle–Based Vaccination with Immunomodulatory Antibodies: Therapeutic Activity in the B16 Melanoma Mouse Model and Immune Correlates in another window
Includes: Supplementary data
Journal Articles

GITR Pathway Activation Abrogates Tumor Immune Suppression through Loss of Regulatory T-cell Lineage Stability

Free
David A. Schaer, Sadna Budhu, Cailian Liu, Campbell Bryson, Nicole Malandro, Adam Cohen, Hong Zhong, Xia Yang, Alan N. Houghton, Taha Merghoub, Jedd D. Wolchok
Journal: Cancer Immunology Research
Cancer Immunol Res (2013) 1 (5): 320–331.
https://doi.org/10.1158/2326-6066.CIR-13-0086
Published: 01 November 2013
View articletitled, GITR Pathway Activation Abrogates Tumor Immune Suppression through Loss of Regulatory T-cell Lineage Stability
Open the PDF for GITR Pathway Activation Abrogates Tumor Immune Suppression through Loss of Regulatory T-cell Lineage Stability in another window
Includes: Supplementary data