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Sabina Signoretti
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Journal Articles

Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma

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Renee Maria Saliby, Talal El Zarif, Ziad Bakouny, Valisha Shah, Wanling Xie, Ronan Flippot, Thomas Denize, M. Harry Kane, Katrine N. Madsen, Miriam Ficial, Laure Hirsch, Xiao X. Wei, John A. Steinharter, Lauren C. Harshman, Ulka N. Vaishampayan, Mariano Severgnini, David F. McDermott, Gwo-Shu Mary Lee, Wenxin Xu, Eliezer M. Van Allen, Bradley A. McGregor, Sabina Signoretti, Toni K. Choueiri, Rana R. McKay, David A. Braun
Journal: Cancer Immunology Research
Cancer Immunol Res (2023) 11 (8): 1114–1124.
https://doi.org/10.1158/2326-6066.CIR-22-0996
Published: 03 August 2023
View articletitled, Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma
Open the PDF for Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1

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Rupal S. Bhatt, Abdulla Berjis, Julie C. Konge, Kathleen M. Mahoney, Alyssa N. Klee, Samuel S. Freeman, Chun-Hau Chen, Opeyemi A. Jegede, Paul J. Catalano, Jean-Christophe Pignon, Maura Sticco-Ivins, Baogong Zhu, Ping Hua, Jo Soden, Jie Zhu, David F. McDermott, Antonio R. Arulanandam, Sabina Signoretti, Gordon J. Freeman
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (2): 156–169.
https://doi.org/10.1158/2326-6066.CIR-20-0315
Published: 03 February 2021
View articletitled, KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1
Open the PDF for KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1 in another window
Includes: Supplementary data
Journal Articles

Mammalian SWI/SNF Complex Genomic Alterations and Immune Checkpoint Blockade in Solid Tumors

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Sarah Abou Alaiwi, Amin H. Nassar, Wanling Xie, Ziad Bakouny, Jacob E. Berchuck, David A. Braun, Sylvan C. Baca, Pier Vitale Nuzzo, Ronan Flippot, Tarek H. Mouhieddine, Liam F. Spurr, Yvonne Y. Li, Taiwen Li, Abdallah Flaifel, John A. Steinharter, Claire A. Margolis, Natalie I. Vokes, Heng Du, Sachet A. Shukla, Andrew D. Cherniack, Guru Sonpavde, Robert I. Haddad, Mark M. Awad, Marios Giannakis, F. Stephen Hodi, X. Shirley Liu, Sabina Signoretti, Cigall Kadoch, Matthew L. Freedman, David J. Kwiatkowski, Eliezer M. Van Allen, Toni K. Choueiri
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (8): 1075–1084.
https://doi.org/10.1158/2326-6066.CIR-19-0866
Published: 03 August 2020
View articletitled, Mammalian SWI/SNF Complex Genomic Alterations and Immune Checkpoint Blockade in Solid Tumors
Open the PDF for Mammalian SWI/SNF Complex Genomic Alterations and Immune Checkpoint Blockade in Solid Tumors in another window
Includes: Supplementary data
Journal Articles

The Clinical Activity of PD-1/PD-L1 Inhibitors in Metastatic Non–Clear Cell Renal Cell Carcinoma

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Rana R. McKay, Dominick Bossé, Wanling Xie, Stephanie A.M. Wankowicz, Abdallah Flaifel, Raphael Brandao, Aly-Khan A. Lalani, Dylan J. Martini, Xiao X. Wei, David A. Braun, Eliezer Van Allen, Daniel Castellano, Guillermo De Velasco, J. Connor Wells, Daniel Y. Heng, Andre P. Fay, Fabio A. Schutz, JoAnn Hsu, Sumanta K. Pal, Jae Lyun Lee, James J. Hsieh, Lauren C. Harshman, Sabina Signoretti, Robert J. Motzer, Darren Feldman, Toni K. Choueiri
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (7): 758–765.
https://doi.org/10.1158/2326-6066.CIR-17-0475
Published: 01 July 2018
View articletitled, The Clinical Activity of PD-1/PD-L1 Inhibitors in Metastatic Non–Clear Cell Renal Cell Carcinoma
Open the PDF for The Clinical Activity of PD-1/PD-L1 Inhibitors in Metastatic Non–Clear Cell Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract A18: Genomic and neoantigen evolution and resistance to immune checkpoint blockade in metastatic renal cell carcinoma

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Diana Miao, Guillermo De Velasco, Dennis Adeegbe, Craig Norton, Dylan Martini, Stephanie Mullane, Raphael Moreira, Sabina Signoretti, Kwok-Kin Wong, Toni Choueiri, Eliezer Van Allen
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (3_Supplement): A18.
https://doi.org/10.1158/2326-6074.TUMIMM16-A18
Published: 28 February 2017
View articletitled, Abstract A18: Genomic and neoantigen evolution and resistance to immune checkpoint blockade in metastatic renal cell carcinoma
Journal Articles

PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells

Free
Kathleen M. Mahoney, Heather Sun, Xiaoyun Liao, Ping Hua, Marcella Callea, Edward A. Greenfield, F. Stephen Hodi, Arlene H. Sharpe, Sabina Signoretti, Scott J. Rodig, Gordon J. Freeman
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2015) 3 (12): 1308–1315.
https://doi.org/10.1158/2326-6066.CIR-15-0116
Published: 06 December 2015
View articletitled, PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells
Open the PDF for PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells in another window
Includes: Supplementary data
Journal Articles

Differential Expression of PD-L1 between Primary and Metastatic Sites in Clear-Cell Renal Cell Carcinoma

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Marcella Callea, Laurence Albiges, Mamta Gupta, Su-Chun Cheng, Elizabeth M. Genega, André P. Fay, Jiaxi Song, Ingrid Carvo, Rupal S. Bhatt, Michael B. Atkins, F. Stephen Hodi, Toni K. Choueiri, David F. McDermott, Gordon J. Freeman, Sabina Signoretti
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (10): 1158–1164.
https://doi.org/10.1158/2326-6066.CIR-15-0043
Published: 04 October 2015
View articletitled, Differential Expression of PD-L1 between Primary and Metastatic Sites in Clear-Cell Renal Cell Carcinoma
Open the PDF for Differential Expression of PD-L1 between Primary and Metastatic Sites in Clear-Cell Renal Cell Carcinoma in another window
Includes: Supplementary data