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Robert H. Vonderheide
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Journal Articles

Abstract IA05: KRAS inhibitors and modulation of inflammation and immunity

Robert H Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2025) 13 (2_Supplement): IA05.
https://doi.org/10.1158/2326-6074.IO2025-IA05
Published: 23 February 2025
View articletitled, Abstract IA05: KRAS inhibitors and modulation of inflammation and immunity
Journal Articles

Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer

Katie E. Blise, Shamilene Sivagnanam, Courtney B. Betts, Konjit Betre, Nell Kirchberger, Benjamin J. Tate, Emma E. Furth, Andressa Dias Costa, Jonathan A. Nowak, Brian M. Wolpin, Robert H. Vonderheide, Jeremy Goecks, Lisa M. Coussens, Katelyn T. Byrne
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (5): 544–558.
https://doi.org/10.1158/2326-6066.CIR-23-0873
Published: 02 May 2024
View articletitled, Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer
Open the PDF for Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Site-Dependent Immune Escape Due to Impaired Dendritic Cell Cross-Priming

Mark S. Diamond, Jeffrey H. Lin, Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (8): 877–890.
https://doi.org/10.1158/2326-6066.CIR-20-0785
Published: 01 August 2021
View articletitled, Site-Dependent Immune Escape Due to Impaired Dendritic Cell Cross-Priming
Open the PDF for Site-Dependent Immune Escape Due to Impaired Dendritic Cell Cross-Priming in another window
Includes: Supplementary data
Journal Articles

Abstract IA02: A case for priming, not checkpoint

Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (2_Supplement): IA02.
https://doi.org/10.1158/2326-6074.TUMIMM20-IA02
Published: 03 February 2021
View articletitled, Abstract IA02: A case for priming, not checkpoint
Journal Articles

Abstract PO015: Tumor-cell-intrinsic epigenetic factors underlie the heterogeneity of immune infiltration and response to immunotherapy in pancreatic cancer

Jinyang Li, Salina Yuan, Robert J. Norgard, Fangxue Yan, Robert H. Vonderheide, Andres Blanco, Ben Z. Stanger
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (2_Supplement): PO015.
https://doi.org/10.1158/2326-6074.TUMIMM20-PO015
Published: 03 February 2021
View articletitled, Abstract PO015: Tumor-cell-intrinsic epigenetic factors underlie the heterogeneity of immune infiltration and response to immunotherapy in pancreatic cancer
Journal Articles

Abstract PR11: Tumor cell-intrinsic factors underlie the heterogeneity of immune infiltration and response to immunotherapy in pancreatic cancer

Jinyang Li, Katelyn T. Byrne, Fangxue Yan, Taiji Yamazoe, Zeyu Chen, Timour Baslan, Lee P. Richman, Jeffrey Lin, Yu H. Sun, Shannon M. Liudahl, John W. Tobias, Scott Lowe, Lisa M. Coussens, John E Wherry, Robert H. Vonderheide, Ben Z. Stanger
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (4_Supplement): PR11.
https://doi.org/10.1158/2326-6074.TUMIMM18-PR11
Published: 01 April 2020
View articletitled, Abstract PR11: Tumor cell-intrinsic factors underlie the heterogeneity of immune infiltration and response to immunotherapy in pancreatic cancer
Journal Articles

Abstract PR14: Emergence of quality metrics for neoantigens: Dissimilarity to the self-proteome as a novel determinant of immunogenicity

Lee P. Richman, Andrew J. Rech, Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (3_Supplement): PR14.
https://doi.org/10.1158/2326-6074.TUMIMM19-PR14
Published: 02 March 2020
View articletitled, Abstract PR14: Emergence of quality metrics for neoantigens: Dissimilarity to the self-proteome as a novel determinant of immunogenicity
Journal Articles

Abstract A054: Tumor cell intrinsic factors dictate immune cell infiltration and response to immunotherapy

Katelyn T. Byrne, Jinyang Li, Robert H. Vonderheide, Ben Stanger
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A054.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A054
Published: 01 February 2019
View articletitled, Abstract A054: Tumor cell intrinsic factors dictate immune cell infiltration and response to immunotherapy
Journal Articles

Tumor Immunity and Survival as a Function of Alternative Neopeptides in Human Cancer

Andrew J. Rech, David Balli, Alejandro Mantero, Hemant Ishwaran, Katherine L. Nathanson, Ben Z. Stanger, Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (3): 276–287.
https://doi.org/10.1158/2326-6066.CIR-17-0559
Published: 28 February 2018
View articletitled, Tumor Immunity and Survival as a Function of Alternative Neopeptides in Human Cancer
Open the PDF for Tumor Immunity and Survival as a Function of Alternative Neopeptides in Human Cancer in another window
Includes: Supplementary data
Journal Articles

Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer

Julia Tchou, Yangbing Zhao, Bruce L. Levine, Paul J Zhang, Megan M. Davis, Jan Joseph Melenhorst, Irina Kulikovskaya, Andrea L Brennan, Xiaojun Liu, Simon F. Lacey, Avery D. Posey, Jr., Austin D. Williams, Alycia So, Jose R. Conejo-Garcia, Gabriela Plesa, Regina M. Young, Shannon McGettigan, Jean Campbell, Robert H. Pierce, Jennifer M. Matro, Angela M. DeMichele, Amy S. Clark, Laurence J. Cooper, Lynn M. Schuchter, Robert H. Vonderheide, Carl H. June
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2017) 5 (12): 1152–1161.
https://doi.org/10.1158/2326-6066.CIR-17-0189
Published: 30 November 2017
View articletitled, Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer
Open the PDF for Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract A12: Analysis of tumor immunogenicity in germline BRCA1/2 mutation associated breast and ovarian cancers

Adam Kraya, Kara N. Maxwell, Brandon M. Wenz, Bradley Wubbenhorst, Daniel De Sloover, Nicole Lunceford, Amanda Barrett, Jennifer D. Morrissette, Michael Feldman, Robert H. Vonderheide, Susan M. Domcheck, Katherine L. Nathanson
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (3_Supplement): A12.
https://doi.org/10.1158/2326-6074.TUMIMM16-A12
Published: 28 February 2017
View articletitled, Abstract A12: Analysis of tumor immunogenicity in germline BRCA1/2 mutation associated breast and ovarian cancers
Journal Articles

CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma

Timothy Chao, Emma E. Furth, Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11): 968–982.
https://doi.org/10.1158/2326-6066.CIR-16-0188
Published: 31 October 2016
View articletitled, CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma
Open the PDF for CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute

Ira Mellman, Vanessa M. Hubbard-Lucey, Matthew J. Tontonoz, Michael D. Kalos, Daniel S. Chen, James P. Allison, Charles G. Drake, Hy Levitsky, Nils Lonberg, Sjoerd H. van der Burg, Douglas T. Fearon, E. John Wherry, Israel Lowy, Robert H. Vonderheide, Patrick Hwu
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (4): 279–288.
https://doi.org/10.1158/2326-6066.CIR-16-0045
Published: 31 March 2016
View articletitled, De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute
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Journal Articles

Abstract A076: CD40 stimulation overrides role of innate immune sensors for priming of T cells in cancer

Katelyn T. Byrne, Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1_Supplement): A076.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR15-A076
Published: 03 January 2016
View articletitled, Abstract A076: CD40 stimulation overrides role of innate immune sensors for priming of T cells in cancer
Journal Articles

Abstract IA45: Prospect of a vaccine to prevent cancer in BRCA1-2 mutation carriers

Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1_Supplement): IA45.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR15-IA45
Published: 03 January 2016
View articletitled, Abstract IA45: Prospect of a vaccine to prevent cancer in BRCA1-2 mutation carriers
Journal Articles

Abstract PR07: Agonistic CD40 antibody combined with chemotherapy drives TLR4/MyD88 independent regression of pancreatic tumors in a T cell dependent manner

Katelyn T. Byrne, Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (10_Supplement): PR07.
https://doi.org/10.1158/2326-6074.TUMIMM14-PR07
Published: 09 October 2015
View articletitled, Abstract PR07: Agonistic CD40 antibody combined with chemotherapy drives TLR4/MyD88 independent regression of pancreatic tumors in a T cell dependent manner
Journal Articles

Abstract IA05: Breaking immune privilege in pancreatic cancer

Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (10_Supplement): IA05.
https://doi.org/10.1158/2326-6074.TUMIMM14-IA05
Published: 09 October 2015
View articletitled, Abstract IA05: Breaking immune privilege in pancreatic cancer
Journal Articles

Abstract A38: Phase I study of combination immunotherapy with agonistic CD40 monoclonal antibody (mAb) CP-870,893 (αCD40) and anti-CTLA-4 antibody tremelimumab (treme) in patients with metastatic melanoma

David L. Bajor, Rosemarie Mick, Matthew J. Riese, Richman P. Lee, Xiaowei Xu, Drew A. Torigian, Erietta Stelekati, Martha Sweeney, Brendan J. Sullivan, Lynn M. Schuchter, Ravi Amaravadi, E John Wherry, Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (10_Supplement): A38.
https://doi.org/10.1158/2326-6074.TUMIMM14-A38
Published: 09 October 2015
View articletitled, Abstract A38: Phase I study of combination immunotherapy with agonistic CD40 monoclonal antibody (mAb) CP-870,893 (αCD40) and anti-CTLA-4 antibody tremelimumab (treme) in patients with metastatic melanoma
Journal Articles

Abstract A52: Radiation and dual PD-L1 and CTLA4 checkpoint blockade non-redundantly improves tumor resistance, response, and immunity

Andrew J. Rech, Christina Twyman, Amit Maity, Ramesh Rengan, Kristen E. Pauken, Erietta Stelekati, Bihui Xu, Hannah Dada, Pamela M. Odorizzi, Ramin D. Herati, Kathleen D. Mansfield, Dana Patsch, Ravi Amaravadi, Lynn Schuchter, Hemant Ishwaran, Rosemarie Mick, Daniel Pryma, George Xu, Michael Feldman, Tara C. Gangadhar, Stephen Hahn, E. John Wherry, Andy J. Minn, Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (10_Supplement): A52.
https://doi.org/10.1158/2326-6074.TUMIMM14-A52
Published: 09 October 2015
View articletitled, Abstract A52: Radiation and dual PD-L1 and CTLA4 checkpoint blockade non-redundantly improves tumor resistance, response, and immunity
Journal Articles

Abstract A40: Agonistic CD40 antibody combined with chemotherapy drives TLR4/MyD88 independent regression of pancreatic tumors in a T cell dependent manner

Katelyn T. Byrne, Robert H. Vonderheide
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (10_Supplement): A40.
https://doi.org/10.1158/2326-6074.TUMIMM14-A40
Published: 09 October 2015
View articletitled, Abstract A40: Agonistic CD40 antibody combined with chemotherapy drives TLR4/MyD88 independent regression of pancreatic tumors in a T cell dependent manner