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Journal Articles

Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer

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Apostolia M. Tsimberidou, Kerstin Guenther, Borje S. Andersson, Regina Mendrzyk, Amir Alpert, Claudia Wagner, Anna Nowak, Katrin Aslan, Arun Satelli, Fabian Richter, Sabrina Kuttruff-Coqui, Oliver Schoor, Jens Fritsche, Zoe Coughlin, Ali S. Mohamed, Kerry Sieger, Becky Norris, Rita Ort, Jennifer Beck, Henry Hiep Vo, Franziska Hoffgaard, Manuel Ruh, Linus Backert, Ignacio I. Wistuba, David Fuhrmann, Nuhad K. Ibrahim, Van Karlyle Morris, Bryan K. Kee, Daniel M. Halperin, Graciela M. Nogueras-Gonzalez, Partow Kebriaei, Elizabeth J. Shpall, David Vining, Patrick Hwu, Harpreet Singh, Carsten Reinhardt, Cedrik M. Britten, Norbert Hilf, Toni Weinschenk, Dominik Maurer, Steffen Walter
Journal: Cancer Immunology Research
Cancer Immunol Res (2023) 11 (7): 925–945.
https://doi.org/10.1158/2326-6066.CIR-22-0444
Published: 05 July 2023
View articletitled, Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Open the PDF for Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer in another window
Includes: Supplementary data
Journal Articles

Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses

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Andrew Fedoriw, Leilei Shi, Shane O'Brien, Kimberly N. Smitheman, Yunfei Wang, Jiakai Hou, Christian Sherk, Satyajit Rajapurkar, Jenny Laraio, Leila J. Williams, Chunyu Xu, Guangchun Han, Qin Feng, Mark T. Bedford, Linghua Wang, Olena Barbash, Ryan G. Kruger, Patrick Hwu, Helai P. Mohammad, Weiyi Peng
Journal: Cancer Immunology Research
Cancer Immunol Res (2022) 10 (4): 420–436.
https://doi.org/10.1158/2326-6066.CIR-21-0614
Published: 01 April 2022
View articletitled, Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses
Open the PDF for Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell–Mediated Antitumor Immune Responses in another window
Includes: Supplementary data
Journal Articles

IL17A Blockade Successfully Treated Psoriasiform Dermatologic Toxicity from Immunotherapy

Free
Daniel Johnson, Anisha B. Patel, Marc I. Uemura, Van A. Trinh, Natalie Jackson, Chrystia M. Zobniw, Michael T. Tetzlaff, Patrick Hwu, Jonathan L. Curry, Adi Diab
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (6): 860–865.
https://doi.org/10.1158/2326-6066.CIR-18-0682
Published: 03 June 2019
View articletitled, IL17A Blockade Successfully Treated Psoriasiform Dermatologic Toxicity from Immunotherapy
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Journal Articles

Abstract B022: Properties of T-cell-recognized neoantigens

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Pia Kvistborg, Marit M. van Buuren, Daisy Philips, Nienke van Rooij, Arno Velds, Sam Behjati, Marlous van den Braber, Mireille Toebes, Lorenzo Fanchi, Maarten Slagter, Marie Stentoft Svane, Patrick Hwu, Joost van den Berg, Michael Stratton, Christian Blank, John B.A.G. Haanen, Can Kesmir, Ton N.M. Schumacher
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): B022.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-B022
Published: 01 February 2019
View articletitled, Abstract B022: Properties of T-cell-recognized neoantigens
Journal Articles

Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance

Free
Livnat Jerby, Parin Shah, Michael S. Cuoco, Christopher Rodman, Mei-Ju Su, Johannes M. Melms, Rachel Leeson, Abhay Kanodia, Shaolin Mei, Jia-Ren Lin, Shu Wang, Bokang Rabasha, David Liu, Gao Zhang, Claire Margolais, Orr Ashenberg, Patrick A. Ott, Elizabeth I. Buchbinder, Riz Haq, Stephen Hodi, Genevieve M. Boland, Ryan J. Sullivan, Dennie Frederick, Benchun Miao, Tabea Moll, Keith Flaherty, Meenhard Herlyn, Russell S. Jenkins, Rohit Thummalapalli, Monika S. Kowalczyk, Israel Canadas, Bastian Schilling, Adam N.R Cartwright, Adrienne M. Luoma, Shruti Malu, Patrick Hwu, Chantale Bernatchez, Marie-Andree Forget, David A. Barbie, Alex K. Shalek, Itay Tirosh, Peter K. Sorger, Kai W. Wucherpfennig, Eliezer M. Van Allen, Dirk Schadendorf, Bruce E. Johnson, Asaf Rotem, Orit Rosenblatt-Rozen, Levi A. Garraway, Charles H. Yoon, Benjamin Izar, Aviv Regev
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A082.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A082
Published: 01 February 2019
View articletitled, Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance
Journal Articles

SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity

Free
Jungsun Park, Amjad H. Talukder, Seon A. Lim, Kwanghee Kim, Ke Pan, Brenda Melendez, Sherille D. Bradley, Kyle R. Jackson, Jahan S. Khalili, Junmei Wang, Caitlin Creasy, Bih-Fang Pan, Scott E. Woodman, Chantale Bernatchez, David Hawke, Patrick Hwu, Kyung-Mi Lee, Jason Roszik, Gregory Lizée, Cassian Yee
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2017) 5 (8): 618–629.
https://doi.org/10.1158/2326-6066.CIR-17-0051
Published: 01 August 2017
View articletitled, SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity
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Includes: Supplementary data
Journal Articles

Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases

Free
Jiemiao Hu, Chantale Bernatchez, Liangfang Zhang, Xueqing Xia, Eugenie S. Kleinerman, Mien-Chie Hung, Patrick Hwu, Shulin Li
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (4): 300–311.
https://doi.org/10.1158/2326-6066.CIR-16-0234
Published: 02 April 2017
View articletitled, Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases
Open the PDF for Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases in another window
Includes: Supplementary data
Journal Articles

Metastatic Melanoma Patient Had a Complete Response with Clonal Expansion after Whole Brain Radiation and PD-1 Blockade

Free
Cara L. Haymaker, DaeWon Kim, Marc Uemura, Luis M. Vence, Ann Phillip, Natalie McQuail, Paul D. Brown, Irina Fernandez, Courtney W. Hudgens, Caitlin Creasy, Wen-Jen Hwu, Padmanee Sharma, Michael T. Tetzlaff, James P. Allison, Patrick Hwu, Chantale Bernatchez, Adi Diab
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (2): 100–105.
https://doi.org/10.1158/2326-6066.CIR-16-0223
Published: 31 January 2017
View articletitled, Metastatic Melanoma Patient Had a Complete Response with Clonal Expansion after Whole Brain Radiation and PD-1 Blockade
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Journal Articles

Abstract B022: Intratumoral CD40 activation and checkpoint blockade induces systemic anti-melanoma immunity that eradicates disseminated tumors

Free
Manisha Singh, Christina Vianden, Adi Diab, Patrick Hwu, Willem W. Overwijk
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): B022.
https://doi.org/10.1158/2326-6066.IMM2016-B022
Published: 31 October 2016
View articletitled, Abstract B022: Intratumoral CD40 activation and checkpoint blockade induces systemic anti-melanoma immunity that eradicates disseminated tumors
Journal Articles

Abstract B110: Topoisomerase I inhibitors enhance efficacy of immunotherapy through a p53 regulatory pathway

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Jodi A. McKenzie, Rina M. Mbofung, Shruti Malu, Rodabe N. Amaria, Emily L. Ashkin, Seram N. Devi, Weiyi Peng, Leila J. Williams, Richard E. Davis, Jason Roszik, Trang N. Tieu, Timothy Heffernan, Patrick Hwu
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): B110.
https://doi.org/10.1158/2326-6066.IMM2016-B110
Published: 31 October 2016
View articletitled, Abstract B110: Topoisomerase I inhibitors enhance efficacy of immunotherapy through a p53 regulatory pathway
Journal Articles

Abstract B118: Using a high throughput T-cell cytotoxicity assay to develop combination strategies for immunotherapy

Free
Leila Williams, Shruti Malu, Jodi McKenzie, Rina Mbofung, Jason Roszik, Patrick Hwu
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): B118.
https://doi.org/10.1158/2326-6066.IMM2016-B118
Published: 31 October 2016
View articletitled, Abstract B118: Using a high throughput T-cell cytotoxicity assay to develop combination strategies for immunotherapy
Journal Articles

Abstract B105: HSP90 inhibitor, ganetespib, enhances responses to cancer immunotherapy through increased expression of interferon response genes

Free
Rina M. Mbofung, Jodi A. McKenzie, Shruti Malu, Chengwen Liu, Weiyi Peng, Isere Kuiatse, Leila Williams, Seram Devi, Zhe Wang, Trang Tieu, Tim Heffernan, Richard E. Davis, Rodabe Amaria, Patrick Hwu
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): B105.
https://doi.org/10.1158/2326-6066.IMM2016-B105
Published: 31 October 2016
View articletitled, Abstract B105: HSP90 inhibitor, ganetespib, enhances responses to cancer immunotherapy through increased expression of interferon response genes
Journal Articles

IL2 Variant Circumvents ICOS+ Regulatory T-cell Expansion and Promotes NK Cell Activation

Free
Geok Choo Sim, Chengwen Liu, Ena Wang, Hui Liu, Caitlin Creasy, Zhimin Dai, Willem W. Overwijk, Jason Roszik, Francesco Marincola, Patrick Hwu, Elizabeth Grimm, Laszlo Radvanyi
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11): 983–994.
https://doi.org/10.1158/2326-6066.CIR-15-0195
Published: 31 October 2016
View articletitled, IL2 Variant Circumvents ICOS+ Regulatory T-cell Expansion and Promotes NK Cell Activation
Open the PDF for IL2 Variant Circumvents ICOS+ Regulatory T-cell Expansion and Promotes NK Cell Activation in another window
Includes: Supplementary data
Journal Articles

Abstract IA19: Rational combinations of targeted and immunotherapies

Free
Weiyi Peng, Rina Mbofung, Leila Williams, Patrick Hwu
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): IA19.
https://doi.org/10.1158/2326-6066.IMM2016-IA19
Published: 31 October 2016
View articletitled, Abstract IA19: Rational combinations of targeted and immunotherapies
Journal Articles

De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute

Free
Ira Mellman, Vanessa M. Hubbard-Lucey, Matthew J. Tontonoz, Michael D. Kalos, Daniel S. Chen, James P. Allison, Charles G. Drake, Hy Levitsky, Nils Lonberg, Sjoerd H. van der Burg, Douglas T. Fearon, E. John Wherry, Israel Lowy, Robert H. Vonderheide, Patrick Hwu
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (4): 279–288.
https://doi.org/10.1158/2326-6066.CIR-16-0045
Published: 31 March 2016
View articletitled, De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute
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Journal Articles

Abstract B152: Increasing the antitumor efficacy of immunotherapy in melanoma by using topoisomerase I inhibitors

Free
Jodi A. McKenzie, Rina M. Mbofung, Shruti Malu, Patrick Hwu
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1_Supplement): B152.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR15-B152
Published: 03 January 2016
View articletitled, Abstract B152: Increasing the antitumor efficacy of immunotherapy in melanoma by using topoisomerase I inhibitors
Journal Articles

Intrathecal Administration of Tumor-Infiltrating Lymphocytes Is Well Tolerated in a Patient with Leptomeningeal Disease from Metastatic Melanoma: A Case Report

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Isabella C. Glitza, Cara Haymaker, Chantale Bernatchez, Luis Vence, Michelle Rohlfs, Jessie Richard, Carol Lacey, Rahmatu Mansaray, Orenthial J. Fulbright, Renjith Ramachandran, Christopher Toth, Seth Wardell, Sapna P. Patel, Scott E. Woodman, Wen-Jen Hwu, Laszlo G. Radvanyi, Michael A. Davies, Nicholas E. Papadopoulos, Patrick Hwu
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (11): 1201–1206.
https://doi.org/10.1158/2326-6066.CIR-15-0071
Published: 04 November 2015
View articletitled, Intrathecal Administration of Tumor-Infiltrating Lymphocytes Is Well Tolerated in a Patient with Leptomeningeal Disease from Metastatic Melanoma: A Case Report
Open the PDF for Intrathecal Administration of Tumor-Infiltrating Lymphocytes Is Well Tolerated in a Patient with Leptomeningeal Disease from Metastatic Melanoma: A Case Report in another window
Journal Articles

BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma

Free
Sherille D. Bradley, Zeming Chen, Brenda Melendez, Amjad Talukder, Jahan S. Khalili, Tania Rodriguez-Cruz, Shujuan Liu, Mayra Whittington, Wanleng Deng, Fenge Li, Chantale Bernatchez, Laszlo G. Radvanyi, Michael A. Davies, Patrick Hwu, Gregory Lizée
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (6): 602–609.
https://doi.org/10.1158/2326-6066.CIR-15-0030
Published: 03 June 2015
View articletitled, BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma
Open the PDF for BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma in another window
Includes: Supplementary data
Journal Articles

PD-L1 Expression in Triple-Negative Breast Cancer

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Elizabeth A. Mittendorf, Anne V. Philips, Funda Meric-Bernstam, Na Qiao, Yun Wu, Susan Harrington, Xiaoping Su, Ying Wang, Ana M. Gonzalez-Angulo, Argun Akcakanat, Akhil Chawla, Michael Curran, Patrick Hwu, Padmanee Sharma, Jennifer K. Litton, Jeffrey J. Molldrem, Gheath Alatrash
Journal: Cancer Immunology Research
Cancer Immunol Res (2014) 2 (4): 361–370.
https://doi.org/10.1158/2326-6066.CIR-13-0127
Published: 03 April 2014
View articletitled, PD-L1 Expression in Triple-Negative Breast Cancer
Open the PDF for PD-L1 Expression in Triple-Negative Breast Cancer in another window
Includes: Supplementary data