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Kai W. Wucherpfennig
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Journal Articles

Immunosuppressive Myeloid Cells Induce Nitric Oxide–Dependent DNA Damage and p53 Pathway Activation in CD8+ T Cells

Adam N.R. Cartwright, Shengbao Suo, Soumya Badrinath, Sushil Kumar, Johannes Melms, Adrienne Luoma, Archis Bagati, Assieh Saadatpour, Benjamin Izar, Guo-Cheng Yuan, Kai W. Wucherpfennig
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (4): 470–485.
https://doi.org/10.1158/2326-6066.CIR-20-0085
Published: 01 April 2021
View article titled, Immunosuppressive Myeloid Cells Induce Nitric Oxide–Dependent DNA Damage and p53 Pathway Activation in CD8<sup>+</sup> T Cells
Open the PDF for Immunosuppressive Myeloid Cells Induce Nitric Oxide–Dependent DNA Damage and p53 Pathway Activation in CD8<sup>+</sup> T Cells in another window
Includes: Supplementary data
Journal Articles

Inhibition of MICA and MICB Shedding Elicits NK-Cell–Mediated Immunity against Tumors Resistant to Cytotoxic T Cells

Lucas Ferrari de Andrade, Sushil Kumar, Adrienne M. Luoma, Yoshinaga Ito, Pedro Henrique Alves da Silva, Deng Pan, Jason W. Pyrdol, Charles H. Yoon, Kai W. Wucherpfennig
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (6): 769–780.
https://doi.org/10.1158/2326-6066.CIR-19-0483
Published: 01 June 2020
View article titled, Inhibition of MICA and MICB Shedding Elicits NK-Cell–Mediated Immunity against Tumors Resistant to Cytotoxic T Cells
Open the PDF for Inhibition of MICA and MICB Shedding Elicits NK-Cell–Mediated Immunity against Tumors Resistant to Cytotoxic T Cells in another window
Includes: Supplementary data
Journal Articles

Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance

Livnat Jerby, Parin Shah, Michael S. Cuoco, Christopher Rodman, Mei-Ju Su, Johannes M. Melms, Rachel Leeson, Abhay Kanodia, Shaolin Mei, Jia-Ren Lin, Shu Wang, Bokang Rabasha, David Liu, Gao Zhang, Claire Margolais, Orr Ashenberg, Patrick A. Ott, Elizabeth I. Buchbinder, Riz Haq, Stephen Hodi, Genevieve M. Boland, Ryan J. Sullivan, Dennie Frederick, Benchun Miao, Tabea Moll, Keith Flaherty, Meenhard Herlyn, Russell S. Jenkins, Rohit Thummalapalli, Monika S. Kowalczyk, Israel Canadas, Bastian Schilling, Adam N.R Cartwright, Adrienne M. Luoma, Shruti Malu, Patrick Hwu, Chantale Bernatchez, Marie-Andree Forget, David A. Barbie, Alex K. Shalek, Itay Tirosh, Peter K. Sorger, Kai W. Wucherpfennig, Eliezer M. Van Allen, Dirk Schadendorf, Bruce E. Johnson, Asaf Rotem, Orit Rosenblatt-Rozen, Levi A. Garraway, Charles H. Yoon, Benjamin Izar, Aviv Regev
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A082.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A082
Published: 01 February 2019
View article titled, Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance
Journal Articles

Abstract A146: Systematic discovery of immune regulatory mechanisms in tumor cells

Deng Pan, Aya Kobayashi, Peng Jiang, Guo-Cheng Yuan, X. Shirley Liu, John Doench, Xintao Qiu, Prakash Rao, Henry Long, Myles A. Brown, Kai W. Wucherpfennig, Lucas Ferrari de Andrade, Rong En Tay, Adrienne M. Luoma, Daphne Tsoucas, Klothilda Lim
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A146.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A146
Published: 01 February 2019
View article titled, Abstract A146: Systematic discovery of immune regulatory mechanisms in tumor cells
Journal Articles

Abstract A176: Overcoming CD8 T-cell suppression in the tumor microenvironment

Adam N.R Cartwright, Peng Jiang, Assieh Saadatpour, Guo-Cheng Yuan, Shirley X. Liu, Kai W. Wucherpfennig
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A176.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A176
Published: 01 February 2019
View article titled, Abstract A176: Overcoming CD8 T-cell suppression in the tumor microenvironment
Journal Articles

Abstract B077: Signatures of T-cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang, Shengqing Gu, Deng Pan, Jingxin Fu, Avinash Sahu, Xihao Hu, Ziyi Li, Nicole Traugh, Xia Bu, Bo Li, Jun Liu, Gordon J Freeman, Myles A Brown, Kai W. Wucherpfennig, Xiaole Shirley Liu
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): B077.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-B077
Published: 01 February 2019
View article titled, Abstract B077: Signatures of T-cell dysfunction and exclusion predict cancer immunotherapy response
Journal Articles

FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors

Viviana Cremasco, Jillian L. Astarita, Angelo L. Grauel, Shilpa Keerthivasan, Kenzie MacIsaac, Matthew C. Woodruff, Michael Wu, Lotte Spel, Stephen Santoro, Zohreh Amoozgar, Tyler Laszewski, Sara Cruz Migoni, Konstantin Knoblich, Anne L. Fletcher, Martin LaFleur, Kai W. Wucherpfennig, Ellen Pure, Glenn Dranoff, Michael C. Carroll, Shannon J. Turley
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2018) 6 (12): 1472–1485.
https://doi.org/10.1158/2326-6066.CIR-18-0098
Published: 03 December 2018
View article titled, FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors
Open the PDF for FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors in another window
Includes: Supplementary data
Journal Articles

Cytotoxic T Cells in PD-L1–Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors

Mark M. Awad, Robert E. Jones, Hongye Liu, Patrick H. Lizotte, Elena V. Ivanova, Meghana Kulkarni, Grit S. Herter-Sprie, Xiaoyun Liao, Abigail A. Santos, Mark A. Bittinger, Lauren Keogh, Shohei Koyama, Christina Almonte, Jessie M. English, Julianne Barlow, William G. Richards, David A. Barbie, Adam J. Bass, Scott J. Rodig, F. Stephen Hodi, Kai W. Wucherpfennig, Pasi A. Jänne, Lynette M. Sholl, Peter S. Hammerman, Kwok-Kin Wong, Raphael Bueno
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (12): 1038–1048.
https://doi.org/10.1158/2326-6066.CIR-16-0171
Published: 30 November 2016
View article titled, Cytotoxic T Cells in PD-L1–Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors
Open the PDF for Cytotoxic T Cells in PD-L1–Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors in another window
Includes: Supplementary data
Journal Articles

Abstract A055: Systematic discovery of combinationimmunotherapy targets in vivo

Adam N. Cartwright, Rong En Tay, Kai W. Wucherpfennig
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): A055.
https://doi.org/10.1158/2326-6066.IMM2016-A055
Published: 31 October 2016
View article titled, Abstract A055: Systematic discovery of combinationimmunotherapy targets in vivo
Journal Articles

The Tumor Microenvironment Shapes Lineage, Transcriptional, and Functional Diversity of Infiltrating Myeloid Cells

Kutlu G. Elpek, Viviana Cremasco, Hua Shen, Christopher J. Harvey, Kai W. Wucherpfennig, Daniel R. Goldstein, Paul A. Monach, Shannon J. Turley
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2014) 2 (7): 655–667.
https://doi.org/10.1158/2326-6066.CIR-13-0209
Published: 01 July 2014
View article titled, The Tumor Microenvironment Shapes Lineage, Transcriptional, and Functional Diversity of Infiltrating Myeloid Cells
Open the PDF for The Tumor Microenvironment Shapes Lineage, Transcriptional, and Functional Diversity of Infiltrating Myeloid Cells in another window
Includes: Supplementary data