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K. Dane Wittrup
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Journal Articles

CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity

Open Access
Naveen K. Mehta, Kavya Rakhra, Kristan A. Meetze, Bochong Li, Noor Momin, Jason Y.H. Chang, K. Dane Wittrup, Patrick A. Baeuerle, Jennifer S. Michaelson
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (8): 1022–1038.
https://doi.org/10.1158/2326-6066.CIR-23-0636
Published: 01 August 2024
View article titled, CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity
Open the PDF for CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity in another window
Includes: Supplementary data
Journal Articles

Anti–PD-1 and Extended Half-life IL2 Synergize for Treatment of Murine Glioblastoma Independent of Host MHC Class I Expression

Available to Purchase
Zachariah P. Tritz, Katayoun Ayasoufi, Delaney M. Wolf, Carley A. Owens, Courtney S. Malo, Benjamin T. Himes, Cori E. Fain, Emma N. Goddery, Lila T. Yokanovich, Fang Jin, Michael J. Hansen, Ian F. Parney, Chensu Wang, Kelly D. Moynihan, Darrell J. Irvine, K. Dane Wittrup, Rosa M. Diaz Marcano, Richard G. Vile, Aaron J. Johnson
Journal: Cancer Immunology Research
Cancer Immunol Res (2023) 11 (6): 763–776.
https://doi.org/10.1158/2326-6066.CIR-22-0570
Published: 02 June 2023
View article titled, Anti–PD-1 and Extended Half-life IL2 Synergize for Treatment of Murine Glioblastoma Independent of Host MHC Class I Expression
Open the PDF for Anti–PD-1 and Extended Half-life IL2 Synergize for Treatment of Murine Glioblastoma Independent of Host MHC Class I Expression in another window
Includes: Supplementary data
Journal Articles

Abstract A52: Eradication of large established tumors with combination immunotherapy engaging innate and adaptive immunity

Free
Kelly Dare Moynihan, Cary Opel, Gregory Szeto, Alice Tzeng, Zhu Eric, Jesse Engreitz, Williams Robert, Kavya Rakhra, Michael Zhang, Adrienne Rothschilds, Sudha Kumari, Ryan L. Kelly, Byron Kwan, Wuhbet Abraham, Kevin Hu, Naveen Mehta, Monique Kauke, Heikyung Suh, Douglas A. Lauffenburger, K. Dane Wittrup, Darrell J. Irvine
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (3_Supplement): A52.
https://doi.org/10.1158/2326-6074.TUMIMM16-A52
Published: 28 February 2017
View article titled, Abstract A52: Eradication of large established tumors with combination immunotherapy engaging innate and adaptive immunity
Journal Articles

Abstract B120: Characterization and combination immunotherapy treatment of an inducible autochthonous murine lung cancer model expressing human carcinoembryonic antigen (CEA) as a tumor-associated self-antigen

Free
Eric F. Zhu, Kavya Rakhra, Naveen Mehta, Kelly D. Moynihan, Cary F. Opel, Darrell J. Irvine, K. Dane Wittrup
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1_Supplement): B120.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR15-B120
Published: 03 January 2016
View article titled, Abstract B120: Characterization and combination immunotherapy treatment of an inducible autochthonous murine lung cancer model expressing human carcinoembryonic antigen (CEA) as a tumor-associated self-antigen
Journal Articles

CD8+ T-cell Responses Rapidly Select for Antigen-Negative Tumor Cells in the Prostate

Free
S. Peter Bak, Mike Stein Barnkob, K. Dane Wittrup, Jianzhu Chen
Journal: Cancer Immunology Research
Cancer Immunol Res (2013) 1 (6): 393–401.
https://doi.org/10.1158/2326-6066.CIR-13-0109
Published: 05 December 2013
View article titled, CD8+ T-cell Responses Rapidly Select for Antigen-Negative Tumor Cells in the Prostate
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