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Jonathan A. Nowak
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Journal Articles

Abstract A052: RNF43 p.G659fs mutation in MSI-high colorectal cancer leads to natural killer cell dysfunction

Pushpamali De Silva, Samantha Fitzgerald, Jules Cazaubiel, Matan Hofree, Tomotaka Ugai, Juha P Väyrynen, Dane Ford-Roshon, Lishan Fang, Ana Garrido-Castro, Nir Hacohen, Kimmie Ng, Shuji Ogino, Jonathan A Nowak, Marios Giannakis
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (10_Supplement): A052.
https://doi.org/10.1158/2326-6074.TUMIMM24-A052
Published: 18 October 2024
View article titled, Abstract A052: <em>RNF43</em> p.G659fs mutation in MSI-high colorectal cancer leads to natural killer cell dysfunction
Journal Articles

Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor

Paul E. Oberstein, Andressa Dias Costa, Emily A. Kawaler, Victoire Cardot-Ruffino, Osama E. Rahma, Nina Beri, Harshabad Singh, Thomas A. Abrams, Leah H. Biller, James M. Cleary, Peter Enzinger, Brandon M. Huffman, Nadine J. McCleary, Kimberly J. Perez, Douglas A. Rubinson, Benjamin L. Schlechter, Rishi Surana, Matthew B. Yurgelun, S. Jennifer Wang, Joshua Remland, Lauren K. Brais, Naima Bollenrucher, Eugena Chang, Lestat R. Ali, Patrick J. Lenehan, Igor Dolgalev, Gregor Werba, Cibelle Lima, C. Elizabeth Keheler, Keri M. Sullivan, Michael Dougan, Cristina Hajdu, Maya Dajee, Marc R. Pelletier, Saloney Nazeer, Matthew Squires, Dafna Bar-Sagi, Brian M. Wolpin, Jonathan A. Nowak, Diane M. Simeone, Stephanie K. Dougan
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (9): 1221–1235.
https://doi.org/10.1158/2326-6066.CIR-23-1073
Published: 03 September 2024
View article titled, Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor
Open the PDF for Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor in another window
Includes: Supplementary data
Journal Articles

Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer

Katie E. Blise, Shamilene Sivagnanam, Courtney B. Betts, Konjit Betre, Nell Kirchberger, Benjamin J. Tate, Emma E. Furth, Andressa Dias Costa, Jonathan A. Nowak, Brian M. Wolpin, Robert H. Vonderheide, Jeremy Goecks, Lisa M. Coussens, Katelyn T. Byrne
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (5): 544–558.
https://doi.org/10.1158/2326-6066.CIR-23-0873
Published: 02 May 2024
View article titled, Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of the Colorectal Cancer Microenvironment

Juha P. Väyrynen, Koichiro Haruki, Mai Chan Lau, Sara A. Väyrynen, Tomotaka Ugai, Naohiko Akimoto, Rong Zhong, Melissa Zhao, Andressa Dias Costa, Jennifer Borowsky, Phoenix Bell, Yasutoshi Takashima, Kenji Fujiyoshi, Kota Arima, Junko Kishikawa, Shan-shan Shi, Tyler S. Twombly, Mingyang Song, Kana Wu, Andrew T. Chan, Xuehong Zhang, Charles S. Fuchs, Jeffrey A. Meyerhardt, Marios Giannakis, Shuji Ogino, Jonathan A. Nowak
Journal: Cancer Immunology Research
Cancer Immunol Res (2022) 10 (2): 215–227.
https://doi.org/10.1158/2326-6066.CIR-21-0772
Published: 03 February 2022
View article titled, Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of the Colorectal Cancer Microenvironment
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Includes: Supplementary data
Journal Articles

The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment

Juha P. Väyrynen, Koichiro Haruki, Mai Chan Lau, Sara A. Väyrynen, Rong Zhong, Andressa Dias Costa, Jennifer Borowsky, Melissa Zhao, Kenji Fujiyoshi, Kota Arima, Tyler S. Twombly, Junko Kishikawa, Simeng Gu, Saina Aminmozaffari, Shanshan Shi, Yoshifumi Baba, Naohiko Akimoto, Tomotaka Ugai, Annacarolina Da Silva, Jennifer L. Guerriero, Mingyang Song, Kana Wu, Andrew T. Chan, Reiko Nishihara, Charles S. Fuchs, Jeffrey A. Meyerhardt, Marios Giannakis, Shuji Ogino, Jonathan A. Nowak
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (1): 8–19.
https://doi.org/10.1158/2326-6066.CIR-20-0527
Published: 04 January 2021
View article titled, The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment
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Includes: Supplementary data
Journal Articles

Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer

Carino Gurjao, David Liu, Matan Hofree, Saud H. AlDubayan, Isaac Wakiro, Mei-Ju Su, Kristen Felt, Evisa Gjini, Lauren K. Brais, Asaf Rotem, Michael H. Rosenthal, Orit Rozenblatt-Rosen, Scott Rodig, Kimmie Ng, Eliezer M. Van Allen, Steven M. Corsello, Shuji Ogino, Aviv Regev, Jonathan A. Nowak, Marios Giannakis
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (8): 1230–1236.
https://doi.org/10.1158/2326-6066.CIR-18-0683
Published: 01 August 2019
View article titled, Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair–Deficient Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status

Tsuyoshi Hamada, Xuehong Zhang, Kosuke Mima, Susan Bullman, Yasutaka Sukawa, Jonathan A. Nowak, Keisuke Kosumi, Yohei Masugi, Tyler S. Twombly, Yin Cao, Mingyang Song, Li Liu, Annacarolina da Silva, Yan Shi, Mancang Gu, Wanwan Li, Hideo Koh, Katsuhiko Nosho, Kentaro Inamura, NaNa Keum, Kana Wu, Jeffrey A. Meyerhardt, Aleksandar D. Kostic, Curtis Huttenhower, Wendy S. Garrett, Matthew Meyerson, Edward L. Giovannucci, Andrew T. Chan, Charles S. Fuchs, Reiko Nishihara, Marios Giannakis, Shuji Ogino
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (11): 1327–1336.
https://doi.org/10.1158/2326-6066.CIR-18-0174
Published: 02 November 2018
View article titled, <em>Fusobacterium nucleatum</em> in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status
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Includes: Supplementary data
Journal Articles

Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer

Yohei Masugi, Reiko Nishihara, Tsuyoshi Hamada, Mingyang Song, Annacarolina da Silva, Keisuke Kosumi, Mancang Gu, Yan Shi, Wanwan Li, Li Liu, Daniel Nevo, Kentaro Inamura, Yin Cao, Xiaoyun Liao, Katsuhiko Nosho, Andrew T. Chan, Marios Giannakis, Adam J. Bass, F. Stephen Hodi, Gordon J. Freeman, Scott J. Rodig, Charles S. Fuchs, Zhi Rong Qian, Jonathan A. Nowak, Shuji Ogino
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (11): 1046–1055.
https://doi.org/10.1158/2326-6066.CIR-17-0122
Published: 31 October 2017
View article titled, Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer
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Includes: Supplementary data
Journal Articles

MicroRNA MIR21 and T Cells in Colorectal Cancer

Kosuke Mima, Reiko Nishihara, Jonathan A. Nowak, Sun A. Kim, Mingyang Song, Kentaro Inamura, Yasutaka Sukawa, Atsuhiro Masuda, Juhong Yang, Ruoxu Dou, Katsuhiko Nosho, Hideo Baba, Edward L. Giovannucci, Michaela Bowden, Massimo Loda, Marios Giannakis, Adam J. Bass, Glenn Dranoff, Gordon J. Freeman, Andrew T. Chan, Charles S. Fuchs, Zhi Rong Qian, Shuji Ogino
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1): 33–40.
https://doi.org/10.1158/2326-6066.CIR-15-0084
Published: 03 January 2016
View article titled, MicroRNA <em>MIR21</em> and T Cells in Colorectal Cancer
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Includes: Supplementary data