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Jedd D. Wolchok
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Journal Articles

Abstract IA22: Immunotherapy for melanoma: Checkpoint blockade combinations

Jedd D. Wolchok
Journal: Cancer Immunology Research
Cancer Immunol Res (2022) 10 (1_Supplement): IA22.
https://doi.org/10.1158/2326-6074.TUMIMM21-IA22
Published: 01 January 2022
View article titled, Abstract IA22: Immunotherapy for melanoma: Checkpoint blockade combinations
Journal Articles

TMB and Inflammatory Gene Expression Associated with Clinical Outcomes following Immunotherapy in Advanced Melanoma

F. Stephen Hodi, Jedd D. Wolchok, Dirk Schadendorf, James Larkin, Georgina V. Long, Xiaozhong Qian, Abdel Saci, Tina C. Young, Sujaya Srinivasan, Han Chang, Hao Tang, Megan Wind-Rotolo, Jasmine I. Rizzo, Donald G. Jackson, Paolo A. Ascierto
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (10): 1202–1213.
https://doi.org/10.1158/2326-6066.CIR-20-0983
Published: 01 October 2021
View article titled, TMB and Inflammatory Gene Expression Associated with Clinical Outcomes following Immunotherapy in Advanced Melanoma
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Includes: Supplementary data
Journal Articles

Abstract PR05: Blockade of AHR activation by IDO/TDO-derived kynurenine restricts cancer immune suppression

Luis F. Campesato, Sadna Budhu, Mathieu Gigoux, Jeremy Tchaicha, Stephane Pourpe, Cailian Liu, Dmitriy Zamarin, Mark G. Manfredi, Karen McGovern, Jedd D. Wolchok, Taha Merghoub
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (4_Supplement): PR05.
https://doi.org/10.1158/2326-6074.TUMIMM18-PR05
Published: 01 April 2020
View article titled, Abstract PR05: Blockade of AHR activation by IDO/TDO-derived kynurenine restricts cancer immune suppression
Journal Articles

Abstract A125: Pulsatile MEK inhibition improves antitumor immunity and T-cell function in Kras mutant lung cancer

Hyejin Choi, Jiehui Deng, Shuai Li, Tarik Silk, Elliott J. Brea, Jonathan Boiarsky, Esra A. Akbay, Paul D. Smith, Taha D. Merghoub, Kwok-Kin Wong, Jedd D. Wolchok
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A125.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A125
Published: 01 February 2019
View article titled, Abstract A125: Pulsatile MEK inhibition improves antitumor immunity and T-cell function in Kras mutant lung cancer
Journal Articles

Abstract PR09: Intratumoral delivery of engineered modified vaccinia virus Ankara expressing Flt3L and OX40L for "in situ" therapeutic cancer vaccination

Liang Deng, Ning Yang, Yi Wang, Wei Yan, Jiahu Wang, John Choi, Stewart Shuman, Taha D. Merghoub, Jedd D. Wolchok
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): PR09.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-PR09
Published: 01 February 2019
View article titled, Abstract PR09: Intratumoral delivery of engineered modified vaccinia virus Ankara expressing Flt3L and OX40L for "in situ" therapeutic cancer vaccination
Journal Articles

Abstract PR01: Mechanistic rationale to combine GITR agonism with PD-1 blockade in cancer patients

Roberta Zappasodi, Cynthia Sirard, Yanyun Li, Sadna Budhu, Moshen Abu-Akeel, Cailian Liu, Xia Yang, Hong Zhong, Walter Newman, Jinjin Qi, Phillip Wong, David Schaer, Henry Koon, Vamsidhar Velcheti, Michael Postow, Margaret K Callahan, Jedd D. Wolchok, Taha D. Merghoub
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): PR01.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-PR01
Published: 01 February 2019
View article titled, Abstract PR01: Mechanistic rationale to combine GITR agonism with PD-1 blockade in cancer patients
Journal Articles

Abstract A006: Phase 1 study to evaluate the safety and tolerability of MEDI4736 (durvalumab, durva) + tremelimumab (treme) in patients with advanced solid tumors

Margaret K. Callahan, Kunle Odunsi, Mario Sznol, John Nemunaitis, Patrick A. Ott, Patrick Dillon, Reva Schneider, Andrew Park, Paul Schwarzenberger, Toni Ricciardi, Mary Macri, Aileen Ryan, Ralph Venhaus, Jedd D. Wolchok
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A006.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A006
Published: 01 February 2019
View article titled, Abstract A006: Phase 1 study to evaluate the safety and tolerability of MEDI4736 (durvalumab, durva) + tremelimumab (treme) in patients with advanced solid tumors
Journal Articles

Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade

Charlotte E. Ariyan, Mary Sue Brady, Robert H. Siegelbaum, Jian Hu, Danielle M. Bello, Jamie Rand, Charles Fisher, Robert A. Lefkowitz, Kathleen S. Panageas, Melissa Pulitzer, Marissa Vignali, Ryan Emerson, Christopher Tipton, Harlan Robins, Taha Merghoub, Jianda Yuan, Achim Jungbluth, Jorge Blando, Padmanee Sharma, Alexander Y. Rudensky, Jedd D. Wolchok, James P. Allison
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2018) 6 (2): 189–200.
https://doi.org/10.1158/2326-6066.CIR-17-0356
Published: 31 January 2018
View article titled, Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade
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Includes: Supplementary data
Journal Articles

Abstract B09: Heterogeneous fates of metastatic lesions linked to immune escape in an ovarian cancer patient

Alejandro Jiménez-Sánchez, Harini Veeraraghavan, Yanyun Li, Hebert Alberto Vargas, Michael B. Gill, Kay J. Park, Oliver Zivanovic, Jason Konner, Jacob Ricca, Dmitriy Zamarin, Carol Aghajanian, Jedd D. Wolchok, Taha Merghoub, Evis Sala, Alexandra Snyder, Martin L. Miller
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (3_Supplement): B09.
https://doi.org/10.1158/2326-6074.TUMIMM16-B09
Published: 28 February 2017
View article titled, Abstract B09: Heterogeneous fates of metastatic lesions linked to immune escape in an ovarian cancer patient
Journal Articles

Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade

Tavi Nathanson, Arun Ahuja, Alexander Rubinsteyn, Bulent Arman Aksoy, Matthew D. Hellmann, Diana Miao, Eliezer Van Allen, Taha Merghoub, Jedd D. Wolchok, Alexandra Snyder, Jeff Hammerbacher
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2017) 5 (1): 84–91.
https://doi.org/10.1158/2326-6066.CIR-16-0019
Published: 03 January 2017
View article titled, Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade
Open the PDF for Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade in another window
Includes: Supplementary data
Journal Articles

Abstract A007: Intratumoral delivery of inactivated vaccinia virus is more efficacious than live oncolytic vaccinia virus in murine bilateral tumor implantation models

Weiyi Wang, Peihong Dai, Ning Yang, Stewart Shuman, Taha Merghoub, Jedd D. Wolchok, Liang Deng
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): A007.
https://doi.org/10.1158/2326-6066.IMM2016-A007
Published: 31 October 2016
View article titled, Abstract A007: Intratumoral delivery of inactivated vaccinia virus is more efficacious than live oncolytic vaccinia virus in murine bilateral tumor implantation models
Journal Articles

Abstract B070: IPI-549-01: A Phase I/Ib first in human study of IPI-549, a PI3K-γ inhibitor, as monotherapy and in combination with an anti-PD-1 antibody in subjects with advanced solid tumors

Anthony Tolcher, David Hong, Ryan Sullivan, James Mier, Geoffrey Shapiro, Joseph Pearlberg, Les Brail, Jahnavi Kharidia, Lixin Han, Claudio Dansky Ullmann, Howard M. Stern, Jedd D. Wolchok
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): B070.
https://doi.org/10.1158/2326-6066.IMM2016-B070
Published: 31 October 2016
View article titled, Abstract B070: IPI-549-01: A Phase I/Ib first in human study of IPI-549, a PI3K-γ inhibitor, as monotherapy and in combination with an anti-PD-1 antibody in subjects with advanced solid tumors
Journal Articles

Abstract PR09: Identifying the epigenetic code of tumor-specific CD8 T cell dysfunction and therapeutic reprogramming

Mary Philip, Lauren Fairchild, Liping Sun, Agnes Viale, Steven Camara, Ellen Horste, Taha Merghoub, Jedd D. Wolchok, Christina S. Leslie, Andrea Schietinger
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): PR09.
https://doi.org/10.1158/2326-6066.IMM2016-PR09
Published: 31 October 2016
View article titled, Abstract PR09: Identifying the epigenetic code of tumor-specific CD8 T cell dysfunction and therapeutic reprogramming
Journal Articles

Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells

Elliott J. Brea, Claire Y. Oh, Eusebio Manchado, Sadna Budhu, Ron S. Gejman, George Mo, Patrizia Mondello, James E. Han, Casey A. Jarvis, David Ulmert, Qing Xiang, Aaron Y. Chang, Ralph J. Garippa, Taha Merghoub, Jedd D. Wolchok, Neal Rosen, Scott W. Lowe, David A. Scheinberg
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11): 936–947.
https://doi.org/10.1158/2326-6066.CIR-16-0177
Published: 31 October 2016
View article titled, Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells
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Includes: Supplementary data
Journal Articles

Abstract PR06: Overcoming intratumor T-cell exclusion by modulation of lactate metabolism to improve immune checkpoint therapies in aggressive breast cancer

Roberta Zappasodi, Arnab Ghosh, Inna Serganova, Ivan Cohen, Yasin Senbabaoglu, Masahiro Shindo, Mayuresh M. Mane, Avigdor Leftin, Ellen Ackerstaff, Jason A. Koutcher, Jedd D. Wolchok, Ronald G. Blasberg, Taha Merghoub
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): PR06.
https://doi.org/10.1158/2326-6066.IMM2016-PR06
Published: 31 October 2016
View article titled, Abstract PR06: Overcoming intratumor T-cell exclusion by modulation of lactate metabolism to improve immune checkpoint therapies in aggressive breast cancer
Journal Articles

Abstract PR05: Peripheral blood immune profiling of anti-PD-1 therapy in human melanoma reveals a link between T cell re-invigoration and tumor burden that predicts response

Alexander Huang, Michael A. Postow, Robert J. Orlowski, Rosemarie Mick, Bertram Bengsch, Sasi Manne, Wei Xu, Shannon Harmon, Matthew Adamow, Deborah Kuk, Katherine Panangeas, Cristina Carerra, Phillip Wong, Felix Quagliarello, Kristen E. Pauken, Ramin S. Herati, Suzanne McGettigan, Shawn Kothari, Sangeeth M. George, Brandon Wenz, Kurt D'Andrea, Xiaowei Xu, Ravi K. Amaravadi, Giorgos Karakousis, Lynn M. Schuchter, Katherine L. Nathanson, Jedd D. Wolchok, Tara C. Gangadhar, John Wherry
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): PR05.
https://doi.org/10.1158/2326-6066.IMM2016-PR05
Published: 31 October 2016
View article titled, Abstract PR05: Peripheral blood immune profiling of anti-PD-1 therapy in human melanoma reveals a link between T cell re-invigoration and tumor burden that predicts response
Journal Articles

Abstract B059: Local intratumoral treatment with low-dose CD40 and TLR4 agonists overcomes resistance to PD-1 blockade to regress tumors systemically

Danny N. Khalil, Luis Felipe Campesato, Yanyun Li, Taha Merghoub, Jedd D. Wolchok
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): B059.
https://doi.org/10.1158/2326-6066.IMM2016-B059
Published: 31 October 2016
View article titled, Abstract B059: Local intratumoral treatment with low-dose CD40 and TLR4 agonists overcomes resistance to PD-1 blockade to regress tumors systemically
Journal Articles

Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy

David B. Page, Jianda Yuan, David Redmond, Y Hanna Wen, Jeremy C. Durack, Ryan Emerson, Stephen Solomon, Zhiwan Dong, Phillip Wong, Christopher Comstock, Adi Diab, Janice Sung, Majid Maybody, Elizabeth Morris, Edi Brogi, Monica Morrow, Virgilio Sacchini, Olivier Elemento, Harlan Robins, Sujata Patil, James P. Allison, Jedd D. Wolchok, Clifford Hudis, Larry Norton, Heather L. McArthur
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (10): 835–844.
https://doi.org/10.1158/2326-6066.CIR-16-0013
Published: 02 October 2016
View article titled, Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy
Open the PDF for Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Autoimmune Bullous Skin Disorders with Immune Checkpoint Inhibitors Targeting PD-1 and PD-L1

Jarushka Naidoo, Katja Schindler, Christiane Querfeld, Klaus Busam, Jane Cunningham, David B. Page, Michael A. Postow, Alyona Weinstein, Anna Skripnik Lucas, Kathryn T. Ciccolini, Elizabeth A. Quigley, Alexander M. Lesokhin, Paul K. Paik, Jamie E. Chaft, Neil H. Segal, Sandra P. D'Angelo, Mark A. Dickson, Jedd D. Wolchok, Mario E. Lacouture
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (5): 383–389.
https://doi.org/10.1158/2326-6066.CIR-15-0123
Published: 01 May 2016
View article titled, Autoimmune Bullous Skin Disorders with Immune Checkpoint Inhibitors Targeting PD-1 and PD-L1
Open the PDF for Autoimmune Bullous Skin Disorders with Immune Checkpoint Inhibitors Targeting PD-1 and PD-L1 in another window
Journal Articles

Abstract B031: Heat-inactivated modified vaccinia virus ankara induces type I IFN and antitumor immunity via the cytosolic DNA-sensing pathway

Peihong Dai, Weiyi Wang, Cristian Serna-Tamayo, Dimitriy Zamarin, Stewart Shuman, Taha Merghoub, Jedd D. Wolchok, Liang Deng
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1_Supplement): B031.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR15-B031
Published: 03 January 2016
View article titled, Abstract B031: Heat-inactivated modified vaccinia virus ankara induces type I IFN and antitumor immunity via the cytosolic DNA-sensing pathway