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Gordon J. Freeman
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Journal Articles

Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity

Peter Georgiev, SeongJun Han, Amy Y. Huang, Thao H. Nguyen, Jefte M. Drijvers, Hannah Creasey, Joseph A. Pereira, Cong-Hui Yao, Joon Seok Park, Thomas S. Conway, Megan E. Fung, Dan Liang, Michael Peluso, Shakchhi Joshi, Jared H. Rowe, Brian C. Miller, Gordon J. Freeman, Arlene H. Sharpe, Marcia C. Haigis, Alison E. Ringel
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (11): 1525–1541.
https://doi.org/10.1158/2326-6066.CIR-24-0463
Published: 04 November 2024
View articletitled, Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
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Includes: Supplementary data
Journal Articles

Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer

Carlos R. Gil Del Alcazar, Anne Trinh, Maša Alečković, Ernesto Rojas Jimenez, Nicholas W. Harper, Michael U.J. Oliphant, Shanshan Xie, Ethan D. Krop, Bethlehem Lulseged, Katherine C. Murphy, Tanya E. Keenan, Eliezer M. Van Allen, Sara M. Tolaney, Gordon J. Freeman, Deborah A. Dillon, Senthil K. Muthuswamy, Kornelia Polyak
Journal: Cancer Immunology Research
Cancer Immunol Res (2022) 10 (6): 680–697.
https://doi.org/10.1158/2326-6066.CIR-21-0804
Published: 03 June 2022
View articletitled, Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer
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Includes: Supplementary data
Journal Articles

Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

Xia Bu, Vikram R. Juneja, Carol G. Reynolds, Kathleen M. Mahoney, Melissa T. Bu, Kathleen A. McGuire, Seth Maleri, Ping Hua, Baogong Zhu, Sarah R. Klein, Edward A. Greenfield, Philippe Armand, Jerome Ritz, Arlene H. Sharpe, Gordon J. Freeman
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (12): 1465–1475.
https://doi.org/10.1158/2326-6066.CIR-21-0493
Published: 01 December 2021
View articletitled, Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses
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Journal Articles

KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1

Rupal S. Bhatt, Abdulla Berjis, Julie C. Konge, Kathleen M. Mahoney, Alyssa N. Klee, Samuel S. Freeman, Chun-Hau Chen, Opeyemi A. Jegede, Paul J. Catalano, Jean-Christophe Pignon, Maura Sticco-Ivins, Baogong Zhu, Ping Hua, Jo Soden, Jie Zhu, David F. McDermott, Antonio R. Arulanandam, Sabina Signoretti, Gordon J. Freeman
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (2): 156–169.
https://doi.org/10.1158/2326-6066.CIR-20-0315
Published: 03 February 2021
View articletitled, KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1
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Includes: Supplementary data
Journal Articles

Abstract PR9: Loss of PD-1 promotes antitumor immunity by improving functions of both PD-1+ and PD-1- CD8+ T cells in the tumor microenvironment

Kristen E. Pauken, Vikram R. Juneja, Alison Ringel, Jared H. Rowe, Kelly P. Burke, Peter T. Sage, Martin W. LaFleur, Juhi R. Kuchroo, Noga Ron-Harel, Seth Maleri, Jaclyn M. Long, Gordon J. Freeman, Nicolas Chevrier, Marcia C. Haigis, Arlene H. Sharpe
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (3_Supplement): PR9.
https://doi.org/10.1158/2326-6074.TUMIMM19-PR9
Published: 02 March 2020
View articletitled, Abstract PR9: Loss of PD-1 promotes antitumor immunity by improving functions of both PD-1+ and PD-1- CD8+ T cells in the tumor microenvironment
Journal Articles

Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL

Ziju Y. Xu-Monette, Min Xiao, Qingyan Au, Raghav Padmanabhan, Bing Xu, Nicholas Hoe, Sandra Rodríguez-Perales, Raul Torres-Ruiz, Ganiraju C. Manyam, Carlo Visco, Yi Miao, Xiaohong Tan, Hongwei Zhang, Alexandar Tzankov, Jing Wang, Karen Dybkær, Wayne Tam, Hua You, Govind Bhagat, Eric D. Hsi, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Miguel A. Piris, J. Han van Krieken, Jane N. Winter, Jason R. Westin, Lan V. Pham, L. Jeffrey Medeiros, George Z. Rassidakis, Yong Li, Gordon J. Freeman, Ken H. Young
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (4): 644–657.
https://doi.org/10.1158/2326-6066.CIR-18-0439
Published: 01 April 2019
View articletitled, Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL
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Includes: Supplementary data
Journal Articles

Abstract B077: Signatures of T-cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang, Shengqing Gu, Deng Pan, Jingxin Fu, Avinash Sahu, Xihao Hu, Ziyi Li, Nicole Traugh, Xia Bu, Bo Li, Jun Liu, Gordon J Freeman, Myles A Brown, Kai W. Wucherpfennig, Xiaole Shirley Liu
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): B077.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-B077
Published: 01 February 2019
View articletitled, Abstract B077: Signatures of T-cell dysfunction and exclusion predict cancer immunotherapy response
Journal Articles

BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer

Dennis O. Adeegbe, Shengwu Liu, Maureen M. Hattersley, Michaela Bowden, Chensheng W. Zhou, Shuai Li, Raven Vlahos, Michael Grondine, Igor Dolgalev, Elena V. Ivanova, Max M. Quinn, Peng Gao, Peter S. Hammerman, James E. Bradner, J. Alan Diehl, Anil K. Rustgi, Adam J. Bass, Aristotelis Tsirigos, Gordon J. Freeman, Huawei Chen, Kwok-Kin Wong
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (10): 1234–1245.
https://doi.org/10.1158/2326-6066.CIR-18-0077
Published: 02 October 2018
View articletitled, BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Abstract A19: PD-1 modulation promotes antitumor immunity by improving metabolic fitness of both PD-1+ and PD-1- CD8+ T cells in the tumor

Kristen E. Pauken, Vikram R. Juneja, Peter T. Sage, Martin W. LaFleur, Juhi R. Kuchroo, Alison Ringel, Noga Ron-Harel, Seth P. Maleri, Gordon J. Freeman, Nicolas Chevrier, Marcia C. Haigis, Arlene H. Sharpe
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (9_Supplement): A19.
https://doi.org/10.1158/2326-6074.TUMIMM17-A19
Published: 01 September 2018
View articletitled, Abstract A19: PD-1 modulation promotes antitumor immunity by improving metabolic fitness of both PD-1+ and PD-1- CD8+ T cells in the tumor
Journal Articles

PD-L1 Binds to B7-1 Only In Cis on the Same Cell Surface

Apoorvi Chaudhri, Yanping Xiao, Alyssa N. Klee, Xiaoxu Wang, Baogong Zhu, Gordon J. Freeman
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2018) 6 (8): 921–929.
https://doi.org/10.1158/2326-6066.CIR-17-0316
Published: 31 July 2018
View articletitled, PD-L1 Binds to B7-1 Only In Cis on the Same Cell Surface
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Includes: Supplementary data
Journal Articles

Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer

Yohei Masugi, Reiko Nishihara, Tsuyoshi Hamada, Mingyang Song, Annacarolina da Silva, Keisuke Kosumi, Mancang Gu, Yan Shi, Wanwan Li, Li Liu, Daniel Nevo, Kentaro Inamura, Yin Cao, Xiaoyun Liao, Katsuhiko Nosho, Andrew T. Chan, Marios Giannakis, Adam J. Bass, F. Stephen Hodi, Gordon J. Freeman, Scott J. Rodig, Charles S. Fuchs, Zhi Rong Qian, Jonathan A. Nowak, Shuji Ogino
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (11): 1046–1055.
https://doi.org/10.1158/2326-6066.CIR-17-0122
Published: 31 October 2017
View articletitled, Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Soluble PD-L1 as a Biomarker in Malignant Melanoma Treated with Checkpoint Blockade

Jun Zhou, Kathleen M. Mahoney, Anita Giobbie-Hurder, Fengmin Zhao, Sandra Lee, Xiaoyun Liao, Scott Rodig, Jingjing Li, Xinqi Wu, Lisa H. Butterfield, Matthias Piesche, Michael P. Manos, Lauren M. Eastman, Glenn Dranoff, Gordon J. Freeman, F. Stephen Hodi
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2017) 5 (6): 480–492.
https://doi.org/10.1158/2326-6066.CIR-16-0329
Published: 01 June 2017
View articletitled, Soluble PD-L1 as a Biomarker in Malignant Melanoma Treated with Checkpoint Blockade
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Includes: Supplementary data
Journal Articles

Abstract B84: Preclinical analysis of combinatorial glioblastoma therapy with the prodrug-mediated gene therapy vector AdV-TK and immune checkpoint inhibition

Maria Carmela Speranza, Franz Ricklefs, Carmela Passaro, Sarah R. Klein, Kazue Kasai, Johanna Kaufmann, Hiroshi Nakashima, Bronisz Agnieszka, Estuardo Aguilar-Cordova, Brian W. Guzik, Gordon J. Freeman, David A. Reardon, Patrick Wen, E. Antonio Chiocca, Sean E. Lawler
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (3_Supplement): B84.
https://doi.org/10.1158/2326-6074.TUMIMM16-B84
Published: 28 February 2017
View articletitled, Abstract B84: Preclinical analysis of combinatorial glioblastoma therapy with the prodrug-mediated gene therapy vector AdV-TK and immune checkpoint inhibition
Journal Articles

Abstract A56: Identification and characterization of an alternative cancer-derived PDL1 isoform

Nadia B. Hassounah, Samuel Freeman, Ellen M. Beauchamp, Chandra S. Pedamallu, Shohei Koyama, Nicholas Souders, Sunil Martin, Esra A. Akbay, Gordon J. Freeman, Glenn Dranoff, Kwok-Kin Wong, Peter S. Hammerman
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (3_Supplement): A56.
https://doi.org/10.1158/2326-6074.TUMIMM16-A56
Published: 28 February 2017
View articletitled, Abstract A56: Identification and characterization of an alternative cancer-derived PDL1 isoform
Journal Articles

Abstract A097: Tumor PDL1 blocks CTL cytotoxicity

Kathleen A. McGuire, Vikram R. Juneja, Robert T. Manguso, Martin W. LaFleur, Natalie Collins, W. Nicholas Haining, Gordon J. Freeman, Arlene H. Sharpe
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): A097.
https://doi.org/10.1158/2326-6066.IMM2016-A097
Published: 31 October 2016
View articletitled, Abstract A097: Tumor PDL1 blocks CTL cytotoxicity
Journal Articles

Abstract A075: Preclinical analysis of combinatorial glioblastoma therapy with the prodrug-mediated gene therapy vector AdV-TK and immune checkpoint inhibition in GBM therapy

Maria Carmela Speranza, Kazue Kasai, Franz Ricklefs, Sarah R. Klein, Carmela Passaro, Hiroshi Nakashima, Johanna Kaufmann, Agnieszka Bronisz, Estuardo Aguilar-Cordova, Brian W. Guzik, Gordon J. Freeman, David A. Reardon, Patrick Wen, E. Antonio Chiocca, Sean E. Lawler
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): A075.
https://doi.org/10.1158/2326-6066.IMM2016-A075
Published: 31 October 2016
View articletitled, Abstract A075: Preclinical analysis of combinatorial glioblastoma therapy with the prodrug-mediated gene therapy vector AdV-TK and immune checkpoint inhibition in GBM therapy
Journal Articles

Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes

Vishwajith Sridharan, Evisa Gjini, Xiaoyun Liao, Nicole G. Chau, Robert I. Haddad, Mariano Severgnini, Peter Hammerman, Adel El-Naggar, Gordon J. Freeman, F. Stephen Hodi, Scott J. Rodig, Glenn Dranoff, Jonathan D. Schoenfeld
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (8): 679–687.
https://doi.org/10.1158/2326-6066.CIR-16-0031
Published: 31 July 2016
View articletitled, Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes
Open the PDF for Immune Profiling of Adenoid Cystic Carcinoma: PD-L2 Expression and Associations with Tumor-Infiltrating Lymphocytes in another window
Includes: Supplementary data
Journal Articles

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

David A. Reardon, Prafulla C. Gokhale, Sarah R. Klein, Keith L. Ligon, Scott J. Rodig, Shakti H. Ramkissoon, Kristen L. Jones, Amy Saur Conway, Xiaoyun Liao, Jun Zhou, Patrick Y. Wen, Annick D. Van Den Abbeele, F. Stephen Hodi, Lei Qin, Nancy E. Kohl, Arlene H. Sharpe, Glenn Dranoff, Gordon J. Freeman
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (2): 124–135.
https://doi.org/10.1158/2326-6066.CIR-15-0151
Published: 01 February 2016
View articletitled, Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model
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Includes: Supplementary data
Journal Articles

MicroRNA MIR21 and T Cells in Colorectal Cancer

Kosuke Mima, Reiko Nishihara, Jonathan A. Nowak, Sun A. Kim, Mingyang Song, Kentaro Inamura, Yasutaka Sukawa, Atsuhiro Masuda, Juhong Yang, Ruoxu Dou, Katsuhiko Nosho, Hideo Baba, Edward L. Giovannucci, Michaela Bowden, Massimo Loda, Marios Giannakis, Adam J. Bass, Glenn Dranoff, Gordon J. Freeman, Andrew T. Chan, Charles S. Fuchs, Zhi Rong Qian, Shuji Ogino
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1): 33–40.
https://doi.org/10.1158/2326-6066.CIR-15-0084
Published: 03 January 2016
View articletitled, MicroRNA MIR21 and T Cells in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells

Kathleen M. Mahoney, Heather Sun, Xiaoyun Liao, Ping Hua, Marcella Callea, Edward A. Greenfield, F. Stephen Hodi, Arlene H. Sharpe, Sabina Signoretti, Scott J. Rodig, Gordon J. Freeman
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2015) 3 (12): 1308–1315.
https://doi.org/10.1158/2326-6066.CIR-15-0116
Published: 06 December 2015
View articletitled, PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells
Open the PDF for PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells in another window
Includes: Supplementary data