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Journal Articles

Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling

Free
Elisa Landoni, Giovanni Fucá, Jian Wang, Venkat R. Chirasani, Zhiyuan Yao, Elena Dukhovlinova, Soldano Ferrone, Barbara Savoldo, Lee K. Hong, Peishun Shou, Silvia Musio, Francesco Padelli, Gaetano Finocchiaro, Miriam Droste, Brian Kuhlman, Abdijapar Shamshiev, Serena Pellegatta, Nikolay V. Dokholyan, Gianpietro Dotti
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (4): 441–453.
https://doi.org/10.1158/2326-6066.CIR-20-0451
Published: 01 April 2021
View articletitled, Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling
Open the PDF for Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling in another window
Includes: Supplementary data
Journal Articles

A High-Avidity T-cell Receptor Redirects Natural Killer T-cell Specificity and Outcompetes the Endogenous Invariant T-cell Receptor

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Elisa Landoni, Christof C. Smith, Giovanni Fucá, Yuhui Chen, Chuang Sun, Benjamin G. Vincent, Leonid S. Metelitsa, Gianpietro Dotti, Barbara Savoldo
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (1): 57–69.
https://doi.org/10.1158/2326-6066.CIR-19-0134
Published: 02 January 2020
View articletitled, A High-Avidity T-cell Receptor Redirects Natural Killer T-cell Specificity and Outcompetes the Endogenous Invariant T-cell Receptor
Open the PDF for A High-Avidity T-cell Receptor Redirects Natural Killer T-cell Specificity and Outcompetes the Endogenous Invariant T-cell Receptor in another window
Includes: Supplementary data
Journal Articles

Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies

Free
Sarah Ahn, Jingjing Li, Chuang Sun, Keliang Gao, Koichi Hirabayashi, Hongxia Li, Barbara Savoldo, Rihe Liu, Gianpietro Dotti
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (5): 773–783.
https://doi.org/10.1158/2326-6066.CIR-18-0636
Published: 01 May 2019
View articletitled, Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies
Open the PDF for Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies in another window
Includes: Supplementary data
Journal Articles

Abstract A025: Eradication of neuroblastoma by T-cells redirected with an optimized GD2-specific chimeric antigen receptor and IL-15

Free
Yuhui Chen, Chuang Sun, Leonid Metelitsa, Gianpietro Dotti, Barbara Savoldo
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A025.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A025
Published: 01 February 2019
View articletitled, Abstract A025: Eradication of neuroblastoma by T-cells redirected with an optimized GD2-specific chimeric antigen receptor and IL-15
Journal Articles

Abstract IA09: Harnessing natural and engineered properties of NKT cells for cancer immunotherapy

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Andras Heczey, Amy N. Courtney, Ho Ngai, Gengwen Tian, Simon N. Robinson, Gianpietro Dotti, Leonid S. Metelitsa
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): IA09.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-IA09
Published: 01 February 2019
View articletitled, Abstract IA09: Harnessing natural and engineered properties of NKT cells for cancer immunotherapy
Journal Articles

CD30-Redirected Chimeric Antigen Receptor T Cells Target CD30+ and CD30− Embryonal Carcinoma via Antigen-Dependent and Fas/FasL Interactions

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Lee K. Hong, Yuhui Chen, Christof C. Smith, Stephanie A. Montgomery, Benjamin G. Vincent, Gianpietro Dotti, Barbara Savoldo
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (10): 1274–1287.
https://doi.org/10.1158/2326-6066.CIR-18-0065
Published: 02 October 2018
View articletitled, CD30-Redirected Chimeric Antigen Receptor T Cells Target CD30+ and CD30− Embryonal Carcinoma via Antigen-Dependent and Fas/FasL Interactions
Open the PDF for CD30-Redirected Chimeric Antigen Receptor T Cells Target CD30+ and CD30− Embryonal Carcinoma via Antigen-Dependent and Fas/FasL Interactions in another window
Includes: Supplementary data
Journal Articles

Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants

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Giedre Krenciute, Brooke L. Prinzing, Zhongzhen Yi, Meng-Fen Wu, Hao Liu, Gianpietro Dotti, Irina V. Balyasnikova, Stephen Gottschalk
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (7): 571–581.
https://doi.org/10.1158/2326-6066.CIR-16-0376
Published: 04 July 2017
View articletitled, Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants
Open the PDF for Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells but Results in Antigen Loss Variants in another window
Includes: Supplementary data
Journal Articles

Abstract A041: CD19-targeting third generation CAR T cells for relapsed and refractory lymphoma and leukemia – report from the Swedish phase I/IIa trial

Free
Gunilla Enblad, Hannah Karlsson, Kristina I. Wikstrom, Magnus Essand, Barbara Savoldo, Malcolm K. Brenner, Gianpietro Dotti, Martin Hoglund, Hans Hagberg, Angelica Loskog
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (1_Supplement): A041.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR15-A041
Published: 03 January 2016
View articletitled, Abstract A041: CD19-targeting third generation CAR T cells for relapsed and refractory lymphoma and leukemia – report from the Swedish phase I/IIa trial
Journal Articles

Abstract B08: Invariant NKT cells as a platform for cancer immunotherapy with chimeric antigen receptors

Free
Andras Heczey, Daofeng Liu, Gengwen Tian, Ekaterina Marinova, Xiuhua Gao, Linjie Guo, John Hicks, Gianpietro Dotti, Leonid Metelitsa
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (10_Supplement): B08.
https://doi.org/10.1158/2326-6074.TUMIMM14-B08
Published: 09 October 2015
View articletitled, Abstract B08: Invariant NKT cells as a platform for cancer immunotherapy with chimeric antigen receptors