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Elizabeth M. Jaffee
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Journal Articles

Abstract B003: Validating PTPN22 as a cancer-agnostic immunotherapeutic target

Jayalaxmi Suresh Babu, Soren Charmsaz, Nicole E Gross, Alexei G Hernandez, Courtney D Cannon, Xuan Yuan, Jianping Lin, Zhong-Yin Zhang, Elizabeth M Jaffee, Won Jin Ho
Journal: Cancer Immunology Research
Cancer Immunol Res (2024) 12 (10_Supplement): B003.
https://doi.org/10.1158/2326-6074.TUMIMM24-B003
Published: 18 October 2024
View article titled, Abstract B003: Validating PTPN22 as a cancer-agnostic immunotherapeutic target
Journal Articles

Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2+ Breast Tumor Microenvironment

Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh, Edgar Gonzalez, Brian J. Christmas, Valerie H. Narumi, Emily F. Davis-Marcisak, Gaurav Sharma, Emma Bigelow, Ajay Vaghasia, Anuj Gupta, Alyza Skaist, Michael Considine, Sarah J. Wheelan, Sathish Kumar Ganesan, Min Yu, Srinivasan Yegnasubramanian, Vered Stearns, Roisin M. Connolly, Daria A. Gaykalova, Luciane T. Kagohara, Elizabeth M. Jaffee, Elana J. Fertig, Evanthia T. Roussos Torres
Journal: Cancer Immunology Research
Cancer Immunol Res (2022) 10 (5): 656–669.
https://doi.org/10.1158/2326-6066.CIR-21-0170
Published: 03 May 2022
View article titled, Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2<sup>+</sup> Breast Tumor Microenvironment
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Includes: Supplementary data
Journal Articles

Context-Dependent Immunomodulatory Effects of MEK Inhibition Are Enhanced with T-cell Agonist Therapy

Lauren Dennison, Amanda Ruggieri, Aditya Mohan, James Leatherman, Kayla Cruz, Skylar Woolman, Nilofer Azad, Gregory B. Lesinski, Elizabeth M. Jaffee, Mark Yarchoan
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (10): 1187–1201.
https://doi.org/10.1158/2326-6066.CIR-21-0147
Published: 01 October 2021
View article titled, Context-Dependent Immunomodulatory Effects of MEK Inhibition Are Enhanced with T-cell Agonist Therapy
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Includes: Supplementary data
Journal Articles

Abstract PO039: Cancer cells educate natural killer cells to a metastasis-promoting cell state

Isaac S. Chan, Hildur Knútsdóttir, Gayathri Ramakrishnan, Veena Padmanaban, Manisha Warrier, Juan Carlos Ramirez, Matthew Dunworth, Hao Zhang, Elizabeth M. Jaffee, Joel S. Bader, Andrew J. Ewald
Journal: Cancer Immunology Research
Cancer Immunol Res (2021) 9 (2_Supplement): PO039.
https://doi.org/10.1158/2326-6074.TUMIMM20-PO039
Published: 03 February 2021
View article titled, Abstract PO039: Cancer cells educate natural killer cells to a metastasis-promoting cell state
Journal Articles

Single-Cell Immune Competency Signatures Associate with Survival in Phase II GVAX and CRS-207 Randomized Studies in Patients with Metastatic Pancreatic Cancer

Nitya Nair, Shih-Yu Chen, Ed Lemmens, Serena Chang, Dung T. Le, Elizabeth M. Jaffee, Aimee Murphy, Chan Whiting, Thomas Müller, Dirk G. Brockstedt
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (5): 609–617.
https://doi.org/10.1158/2326-6066.CIR-19-0650
Published: 01 May 2020
View article titled, Single-Cell Immune Competency Signatures Associate with Survival in Phase II GVAX and CRS-207 Randomized Studies in Patients with Metastatic Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Abstract IA01: Turning the heat up on pancreatic cancer: Lessons on overcoming a “cold” immunologic microenvironment

Elizabeth M. Jaffee
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (4_Supplement): IA01.
https://doi.org/10.1158/2326-6074.TUMIMM18-IA01
Published: 01 April 2020
View article titled, Abstract IA01: Turning the heat up on pancreatic cancer: Lessons on overcoming a “cold” immunologic microenvironment
Journal Articles

Abstract B68: NF-kB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma

Rahul R. Suresh, David J. Barakat, Theresa Barberi, Lei Zheng, Elizabeth M. Jaffee, Kenneth J. Pienta, Alan D. Friedman
Journal: Cancer Immunology Research
Cancer Immunol Res (2020) 8 (3_Supplement): B68.
https://doi.org/10.1158/2326-6074.TUMIMM19-B68
Published: 02 March 2020
View article titled, Abstract B68: NF-kB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma
Journal Articles

Immunopathologic Stratification of Colorectal Cancer for Checkpoint Blockade Immunotherapy

Nicolas J. Llosa, Brandon Luber, Nicholas Siegel, Anas H. Awan, Teniola Oke, Qingfeng Zhu, Bjarne R. Bartlett, Laveet K. Aulakh, Elizabeth D. Thompson, Elizabeth M. Jaffee, Jennifer N. Durham, Cynthia L. Sears, Dung T. Le, Luis A. Diaz, Jr, Drew M. Pardoll, Hao Wang, Franck Housseau, Robert A. Anders
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2019) 7 (10): 1574–1579.
https://doi.org/10.1158/2326-6066.CIR-18-0927
Published: 01 October 2019
View article titled, Immunopathologic Stratification of Colorectal Cancer for Checkpoint Blockade Immunotherapy
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Includes: Supplementary data
Journal Articles

Programmed Cell Death Ligand-1 (PD-L1) and CD8 Expression Profiling Identify an Immunologic Subtype of Pancreatic Ductal Adenocarcinomas with Favorable Survival

Ludmila Danilova, Won Jin Ho, Qingfeng Zhu, Teena Vithayathil, Ana De Jesus-Acosta, Nilofer S. Azad, Daniel A. Laheru, Elana J. Fertig, Robert Anders, Elizabeth M. Jaffee, Mark Yarchoan
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (6): 886–895.
https://doi.org/10.1158/2326-6066.CIR-18-0822
Published: 03 June 2019
View article titled, Programmed Cell Death Ligand-1 (PD-L1) and CD8 Expression Profiling Identify an Immunologic Subtype of Pancreatic Ductal Adenocarcinomas with Favorable Survival
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Includes: Supplementary data
Journal Articles

Multiple Immune-Suppressive Mechanisms in Fibrolamellar Carcinoma

Amy K. Kim, Faiz Gani, Andrew J. Layman, Sepideh Besharati, Qingfeng Zhu, Farah Succaria, Elizabeth L. Engle, Feriyl Bhaijee, Maria B. Goggins, Nicolas J. Llosa, Timothy M. Pawlik, Mark Yarchoan, Elizabeth M. Jaffee, Howard C. Simons, Janis M. Taube, Robert A. Anders
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (5): 805–812.
https://doi.org/10.1158/2326-6066.CIR-18-0499
Published: 01 May 2019
View article titled, Multiple Immune-Suppressive Mechanisms in Fibrolamellar Carcinoma
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Includes: Supplementary data
Journal Articles

A CD40 Agonist and PD-1 Antagonist Antibody Reprogram the Microenvironment of Nonimmunogenic Tumors to Allow T-cell–Mediated Anticancer Activity

Hayley S. Ma, Bibhav Poudel, Evanthia Roussos Torres, John-William Sidhom, Tara M. Robinson, Brian Christmas, Blake Scott, Kayla Cruz, Skylar Woolman, Valerie Z. Wall, Todd Armstrong, Elizabeth M. Jaffee
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (3): 428–442.
https://doi.org/10.1158/2326-6066.CIR-18-0061
Published: 01 March 2019
View article titled, A CD40 Agonist and PD-1 Antagonist Antibody Reprogram the Microenvironment of Nonimmunogenic Tumors to Allow T-cell–Mediated Anticancer Activity
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Includes: Supplementary data
Journal Articles

Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into Checkpoint-Responsive Tumors by Reprogramming Tumor-Infiltrating MDSCs

Brian J. Christmas, Christine I. Rafie, Alexander C. Hopkins, Blake A. Scott, Hayley S. Ma, Kayla A. Cruz, Skylar Woolman, Todd D. Armstrong, Roisin M. Connolly, Nilo A. Azad, Elizabeth M. Jaffee, Evanthia T. Roussos Torres
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (12): 1561–1577.
https://doi.org/10.1158/2326-6066.CIR-18-0070
Published: 03 December 2018
View article titled, Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into Checkpoint-Responsive Tumors by Reprogramming Tumor-Infiltrating MDSCs
Open the PDF for Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into Checkpoint-Responsive Tumors by Reprogramming Tumor-Infiltrating MDSCs in another window
Includes: Supplementary data
Journal Articles

Report on the Third FDA–AACR Oncology Dose-Finding Workshop

Leisha A. Emens, Rene Bruno, Eric H. Rubin, Elizabeth M. Jaffee, Amy E. McKee
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (12): 1058–1061.
https://doi.org/10.1158/2326-6066.CIR-17-0590
Published: 30 November 2017
View article titled, Report on the Third FDA–AACR Oncology Dose-Finding Workshop
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Journal Articles

A Blueprint to Advance Colorectal Cancer Immunotherapies

Dung T. Le, Vanessa M. Hubbard-Lucey, Michael A. Morse, Christopher R. Heery, Andrea Dwyer, Thomas H. Marsilje, Arthur N. Brodsky, Emily Chan, Dustin A. Deming, Luis A. Diaz, Jr, Wolf H. Fridman, Richard M. Goldberg, Stanley R. Hamilton, Franck Housseau, Elizabeth M. Jaffee, S. Peter Kang, Smitha S. Krishnamurthi, Christopher H. Lieu, Wells Messersmith, Cynthia L. Sears, Neil H. Segal, Arvin Yang, Rebecca A. Moss, Edward Cha, Jill O'Donnell-Tormey, Nancy Roach, Anjelica Q. Davis, Keavy McAbee, Sharyn Worrall, Al B. Benson
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2017) 5 (11): 942–949.
https://doi.org/10.1158/2326-6066.CIR-17-0375
Published: 31 October 2017
View article titled, A Blueprint to Advance Colorectal Cancer Immunotherapies
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Includes: Supplementary data
Journal Articles

A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice

Jeremy B. Foote, Marleen Kok, James M. Leatherman, Todd D. Armstrong, Bridget C. Marcinkowski, Laureen S. Ojalvo, David B. Kanne, Elizabeth M. Jaffee, Thomas W. Dubensky, Jr, Leisha A. Emens
Journal: Cancer Immunology Research
Cancer Immunol Res (2017) 5 (6): 468–479.
https://doi.org/10.1158/2326-6066.CIR-16-0284
Published: 01 June 2017
View article titled, A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice
Open the PDF for A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice in another window
Includes: Supplementary data
Journal Articles

Abstract IA26: Combinatorial immunotherapies with the potential to reverse the carcinogenesis process

Elizabeth M. Jaffee
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (11_Supplement): IA26.
https://doi.org/10.1158/2326-6066.IMM2016-IA26
Published: 31 October 2016
View article titled, Abstract IA26: Combinatorial immunotherapies with the potential to reverse the carcinogenesis process
Journal Articles

Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer

Darshil T. Jhaveri, Min-Sik Kim, Elizabeth D. Thompson, Lanqing Huang, Rajni Sharma, Alison P. Klein, Lei Zheng, Dung T. Le, Daniel A. Laheru, Akhilesh Pandey, Elizabeth M. Jaffee, Robert A. Anders
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2016) 4 (3): 225–233.
https://doi.org/10.1158/2326-6066.CIR-15-0200-T
Published: 29 February 2016
View article titled, Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Special Conference on Tumor Immunology and Immunotherapy: A New Chapter

Katelyn T. Byrne, Robert H. Vonderheide, Elizabeth M. Jaffee, Todd D. Armstrong
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (6): 590–597.
https://doi.org/10.1158/2326-6066.CIR-15-0106
Published: 03 June 2015
View article titled, Special Conference on Tumor Immunology and Immunotherapy: A New Chapter
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Journal Articles

A Feasibility Study of Cyclophosphamide, Trastuzumab, and an Allogeneic GM-CSF–Secreting Breast Tumor Vaccine for HER2+ Metastatic Breast Cancer

Gang Chen, Richa Gupta, Silvia Petrik, Marina Laiko, James M. Leatherman, Justin M. Asquith, Maithili M. Daphtary, Elizabeth Garrett-Mayer, Nancy E. Davidson, Kellie Hirt, Maureen Berg, Jennifer N. Uram, Tianna Dauses, John Fetting, Elizabeth M. Duus, Saadet Atay-Rosenthal, Xiaobu Ye, Antonio C. Wolff, Vered Stearns, Elizabeth M. Jaffee, Leisha A. Emens
Journal: Cancer Immunology Research
Cancer Immunol Res (2014) 2 (10): 949–961.
https://doi.org/10.1158/2326-6066.CIR-14-0058
Published: 02 October 2014
View article titled, A Feasibility Study of Cyclophosphamide, Trastuzumab, and an Allogeneic GM-CSF–Secreting Breast Tumor Vaccine for HER2<sup>+</sup> Metastatic Breast Cancer
Open the PDF for A Feasibility Study of Cyclophosphamide, Trastuzumab, and an Allogeneic GM-CSF–Secreting Breast Tumor Vaccine for HER2<sup>+</sup> Metastatic Breast Cancer in another window
Journal Articles

Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation

Eric R. Lutz, Annie A. Wu, Elaine Bigelow, Rajni Sharma, Guanglan Mo, Kevin Soares, Sara Solt, Alvin Dorman, Anthony Wamwea, Allison Yager, Daniel Laheru, Christopher L. Wolfgang, Jiang Wang, Ralph H. Hruban, Robert A. Anders, Elizabeth M. Jaffee, Lei Zheng
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2014) 2 (7): 616–631.
https://doi.org/10.1158/2326-6066.CIR-14-0027
Published: 01 July 2014
View article titled, Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation
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Includes: Supplementary data