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Journal Articles

Immunological features in de novo and recurrent glioblastoma associate with survival outcomes

Cecile Alanio, Zev A. Binder, Renee B. Chang, MacLean P. Nasrallah, Devora Delman, Joey H. Li, Oliver Y. Tang, Logan Y. Zhang, Jiasi Vicky Zhang, E. John Wherry, Donald M. O'Rourke, Gregory L. Beatty

Cancer Immunol Res canimm.CIR-21-1050-E.2021.

DOI: https://doi.org/10.1158/2326-6066.CIR-21-1050

Published: 04 May 2022

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Includes: Supplementary data

Journal Articles

Abstract IA07: Impact of immunotherapy on COVID-19 immunity: Insights from checkpoint blockade in cancer

Paulina Coutifaris, Kevin Wang, Sokratis Apostolidis, Mark Painter, Ahron Flowers, Rishi Goel, Divij Mathew, Ajinkya Pattekar, Ravi Amaravadi, Tara Mitchell, Paul Bates, Scott Hensley, Giorgos Karakousis, Lynn Schuchter, Allie Greenplate, E. John Wherry, Alexander C. Huang

Cancer Immunol Res (2022) 10 (1_Supplement): IA07.

DOI: https://doi.org/10.1158/2326-6074.TUMIMM21-IA07

Published: 01 January 2022

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Journal Articles

Abstract PO068: Distinct immune signatures predicting clinical response to PD-1 blockade therapy in gynecological cancers revealed by high-dimensional immune profiling

Yuki Muroyama, Sasikanth Manne, Alexander C. Huang, Divij Mathew, Lakshmi Chilukuri, Allison R. Greenplate, Takuya Ohtani, Dmitriy Zamarin, Claire F. Friedman, E. John Wherry

Cancer Immunol Res (2021) 9 (2_Supplement): PO068.

DOI: https://doi.org/10.1158/2326-6074.TUMIMM20-PO068

Published: 03 February 2021

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Journal Articles

Abstract IA17: Molecular mechanisms of T-cell exhaustion and implications for immunotherapy

E. John Wherry

Cancer Immunol Res (2020) 8 (4_Supplement): IA17.

DOI: https://doi.org/10.1158/2326-6074.TUMIMM18-IA17

Published: 01 April 2020

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Journal Articles

Abstract B80: High dimensional DNA damage and repair (DDR) cytometric profiling of human T cell subsets revealed distinct DDR signatures

Yuki Muroyama, Alexander C. Huang, Sasikanth Manne, Ramin S. Herati, Lakshmi Chilukuri, Caiyue Xu, Claire F. Friedman, Dmitriy Zamarin, E. John Wherry

Cancer Immunol Res (2020) 8 (3_Supplement): B80.

DOI: https://doi.org/10.1158/2326-6074.TUMIMM19-B80

Published: 02 March 2020

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Journal Articles

Abstract B012: Characterizing tumor-induced exhaustion in melanoma patients treated with neoadjuvant pembrolizumab

Josephine R. Giles, Alexander C. Huang, Saskinath Manne, Jorge Henao-Meji, E. John Wherry

Cancer Immunol Res (2019) 7 (2_Supplement): B012.

DOI: https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-B012

Published: 01 February 2019

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Journal Articles

Abstract A123: Skewed CD4 and CD8 T-cell differentiation in pancreatic cancer patients

Cecile Alanio, Bertram Bengsch, Josephine R. Gies, Sarah Henrickson, Nan Ping Weng, Janáe A Ritz-Romeo, Mark O'Hara, Joseph J Melenhorst, Simon Lacey, Regina M Young, Carl H June, E. John Wherry

Cancer Immunol Res (2019) 7 (2_Supplement): A123.

DOI: https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A123

Published: 01 February 2019

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Journal Articles

Abstract A197: The HMG transcription factor TOX induces a transcriptional and epigenetic program of CD8+ T-cell exhaustion in chronic infection and cancer

Omar Khan, Josephine R. Giles, Sierra McDonald, E. John Wherry

Cancer Immunol Res (2019) 7 (2_Supplement): A197.

DOI: https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A197

Published: 01 February 2019

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Journal Articles

Abstract A166: Reprogramming of exhausted T-cells following cure of chronic viral infection

Mohamed S. Abdel-Hakeem, Jean-Christophe Beltra, Zeyu Chen, John Johnson, Saskinath Manne, Mohammed-Alkhatim Ali, E. John Wherry

Cancer Immunol Res (2019) 7 (2_Supplement): A166.

DOI: https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A166

Published: 01 February 2019

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Journal Articles

Abstract B104: Impact of PD-1 blockade on epigenetic and transcriptional reprogramming of exhausted T cells

Kristen E. Pauken, Morgan A. Sammons, Pamela M. Odorizzi, Sasi K. Manne, Jernej Godec, Omar Khan, Debattama Sen, Makoto Kurachi, R. Anthony Barnitz, Bertram Bengsch, Alexander C. Huang, Jason M. Schenkel, Golnaz Vahedi, W. Nicholas Haining, Shelley L. Berger, E. John Wherry

Cancer Immunol Res (2016) 4 (11_Supplement): B104.

DOI: https://doi.org/10.1158/2326-6066.IMM2016-B104

Published: 31 October 2016

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Journal Articles

Abstract IA06: Molecular basis of T cell exhaustion: Insights for immunotherapy

E. John Wherry

Cancer Immunol Res (2016) 4 (11_Supplement): IA06.

DOI: https://doi.org/10.1158/2326-6066.IMM2016-IA06

Published: 31 October 2016

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Journal Articles

De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute

Ira Mellman, Vanessa M. Hubbard-Lucey, Matthew J. Tontonoz, Michael D. Kalos, Daniel S. Chen, James P. Allison, Charles G. Drake, Hy Levitsky, Nils Lonberg, Sjoerd H. van der Burg, Douglas T. Fearon, E. John Wherry, Israel Lowy, Robert H. Vonderheide, Patrick Hwu

Cancer Immunol Res (2016) 4 (4): 279–288.

DOI: https://doi.org/10.1158/2326-6066.CIR-16-0045

Published: 31 March 2016

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Journal Articles

Abstract A056: Mechanisms of tumor response and resistance to radiation and dual checkpoint blockade in mice and patients

Cancer Immunol Res (2016) 4 (1_Supplement): A056.

DOI: https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR15-A056

Published: 03 January 2016

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Journal Articles

Abstract A38: Phase I study of combination immunotherapy with agonistic CD40 monoclonal antibody (mAb) CP-870,893 (αCD40) and anti-CTLA-4 antibody tremelimumab (treme) in patients with metastatic melanoma

David L. Bajor, Rosemarie Mick, Matthew J. Riese, Richman P. Lee, Xiaowei Xu, Drew A. Torigian, Erietta Stelekati, Martha Sweeney, Brendan J. Sullivan, Lynn M. Schuchter, Ravi Amaravadi, E John Wherry, Robert H. Vonderheide

Cancer Immunol Res (2015) 3 (10_Supplement): A38.

DOI: https://doi.org/10.1158/2326-6074.TUMIMM14-A38

Published: 09 October 2015

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Journal Articles

Abstract A52: Radiation and dual PD-L1 and CTLA4 checkpoint blockade non-redundantly improves tumor resistance, response, and immunity

Cancer Immunol Res (2015) 3 (10_Supplement): A52.

DOI: https://doi.org/10.1158/2326-6074.TUMIMM14-A52

Published: 09 October 2015

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Journal Articles

Abstract IA01: Molecular basis of T cell exhaustion: Insights for immunotherapy

E. John Wherry

Cancer Immunol Res (2015) 3 (10_Supplement): IA01.

DOI: https://doi.org/10.1158/2326-6074.TUMIMM14-IA01

Published: 09 October 2015

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Journal Articles

Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma

Rafael Winograd, Katelyn T. Byrne, Rebecca A. Evans, Pamela M. Odorizzi, Anders R.L. Meyer, David L. Bajor, Cynthia Clendenin, Ben Z. Stanger, Emma E. Furth, E. John Wherry, Robert H. Vonderheide

Cancer Immunol Res (2015) 3 (4): 399–411.

DOI: https://doi.org/10.1158/2326-6066.CIR-14-0215

Published: 05 April 2015

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Includes: Supplementary data

NARROW

Immunological features in de novo and recurrent glioblastoma associate with survival outcomes

Abstract IA07: Impact of immunotherapy on COVID-19 immunity: Insights from checkpoint blockade in cancer

Abstract PO068: Distinct immune signatures predicting clinical response to PD-1 blockade therapy in gynecological cancers revealed by high-dimensional immune profiling

Abstract IA17: Molecular mechanisms of T-cell exhaustion and implications for immunotherapy

Abstract B80: High dimensional DNA damage and repair (DDR) cytometric profiling of human T cell subsets revealed distinct DDR signatures

Abstract B012: Characterizing tumor-induced exhaustion in melanoma patients treated with neoadjuvant pembrolizumab

Abstract A123: Skewed CD4 and CD8 T-cell differentiation in pancreatic cancer patients

Abstract A197: The HMG transcription factor TOX induces a transcriptional and epigenetic program of CD8+ T-cell exhaustion in chronic infection and cancer

Abstract A166: Reprogramming of exhausted T-cells following cure of chronic viral infection

Abstract B104: Impact of PD-1 blockade on epigenetic and transcriptional reprogramming of exhausted T cells

Abstract IA06: Molecular basis of T cell exhaustion: Insights for immunotherapy

De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute

Abstract A056: Mechanisms of tumor response and resistance to radiation and dual checkpoint blockade in mice and patients

Abstract A38: Phase I study of combination immunotherapy with agonistic CD40 monoclonal antibody (mAb) CP-870,893 (αCD40) and anti-CTLA-4 antibody tremelimumab (treme) in patients with metastatic melanoma

Abstract A52: Radiation and dual PD-L1 and CTLA4 checkpoint blockade non-redundantly improves tumor resistance, response, and immunity

Abstract IA01: Molecular basis of T cell exhaustion: Insights for immunotherapy

Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma

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