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David A. Barbie
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Journal Articles

Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor That Unleashes PD-1 Checkpoint and CAR T-Cell Immunotherapies

Open Access
Michael Wichroski, Si-Qi Liu, Lauren M. Zasadil, Joseph L. Benci, Patrick C. Gedeon, Kendall J. Condon, Suhasini Joshi, Shana Posy, Patrick Carlson, Alison Maier, Jiao Shen, Rakeeb Kureshi, Yuka Amako, Tai Wang, Ryan L. Powles, Yanyun Li, Tho Lai, Igor Katsyv, Hongchen Qiu, Huilin Qi, Jessica Wong, Dandan Zhao, Dana Banas, Joelle Onorato, Gregory Locke, Xueer Chen, Wen-Chi Chou, Erica Cook, Abigail E. Witt, Christopher M. Barbieri, Hong Zhang, Jonathan B. Olsen, Alba Font-Tello, Eugene Drokhlyansky, Denise C. Grünenfelder, Louis Chupak, Tyler A. Longmire, Jon C. Jones, Travis J. Hollmann, David G. Kugler, John N. Feder, Raphael Bueno, John Wain, Pallavur Sivakumar, Yu Liu, Stephanie K. Dougan, Cloud P. Paweletz, David A. Barbie, Emma Lees
Journal: Cancer Immunology Research
Cancer Immunol Res (2025)
https://doi.org/10.1158/2326-6066.CIR-25-0156
Published: 12 June 2025
View articletitled, Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor That Unleashes PD-1 Checkpoint and CAR T-Cell Immunotherapies
Open the PDF for Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor That Unleashes PD-1 Checkpoint and CAR T-Cell Immunotherapies in another window
Includes: Supplementary data
Journal Articles

EDIL3 as an Angiogenic Target of Immune Exclusion Following Checkpoint Blockade

Open Access
Saba Tabasum, Dinesh Thapa, Anita Giobbie-Hurder, Jason L. Weirather, Marco Campisi, Pieter J. Schol, Xiaoyu Li, Jingjing Li, Charles H. Yoon, Michael P. Manos, David A. Barbie, F. Stephen Hodi
Journal: Cancer Immunology Research
Cancer Immunol Res (2023) 11 (11): 1493–1507.
https://doi.org/10.1158/2326-6066.CIR-23-0171
Published: 01 November 2023
View articletitled, EDIL3 as an Angiogenic Target of Immune Exclusion Following Checkpoint Blockade
Open the PDF for EDIL3 as an Angiogenic Target of Immune Exclusion Following Checkpoint Blockade in another window
Includes: Supplementary data
Journal Articles

Abstract A08: Divergent tumor cell states in neuroblastoma possess distinct immunogenic phenotypes

Free
Satyaki Sengupta, Sanjukta Das, Angela C. Crespo, Annelisa M. Cornel, Anand G. Patel, Navin R. Mahadevan, Marco Campisi, Alaa K. Ali, Bandana Sharma, Jared H. Rowe, Rogier Versteeg, Rudolf Jaenisch, Stefani Spranger, Rizwan Romee, Brian C. Miller, David A. Barbie, Stefan Nierkens, Michael A. Dyer, Judy Lieberman, Rani E. George
Journal: Cancer Immunology Research
Cancer Immunol Res (2022) 10 (12_Supplement): A08.
https://doi.org/10.1158/2326-6074.TUMIMM22-A08
Published: 01 December 2022
View articletitled, Abstract A08: Divergent tumor cell states in neuroblastoma possess distinct immunogenic phenotypes
Journal Articles

Activation of Tumor-Cell STING Primes NK-Cell Therapy

Free
Erik H. Knelson, Elena V. Ivanova, Mubin Tarannum, Marco Campisi, Patrick H. Lizotte, Matthew A. Booker, Ismail Ozgenc, Moataz Noureddine, Brittany Meisenheimer, Minyue Chen, Brandon Piel, Nathaniel Spicer, Bonje Obua, Cameron M. Messier, Erin Shannon, Navin R. Mahadevan, Tetsuo Tani, Pieter J. Schol, Anna M. Lee-Hassett, Ari Zlota, Ha V. Vo, Minh Ha, Arrien A. Bertram, Saemi Han, Tran C. Thai, Corinne E. Gustafson, Kartika Venugopal, Timothy J. Haggerty, Thomas P. Albertson, Antja-Voy Hartley, Pinar O. Eser, Ze-Hua Li, Israel Cañadas, Marina Vivero, Assunta De Rienzo, William G. Richards, Adnan O. Abu-Yousif, Vicky A. Appleman, Richard C. Gregory, Alexander Parent, Neil Lineberry, Eric L. Smith, Pasi A. Jänne, Juan J. Miret, Michael Y. Tolstorukov, Rizwan Romee, Cloud P. Paweletz, Raphael Bueno, David A. Barbie
Journal: Cancer Immunology Research
Cancer Immunol Res (2022) 10 (8): 947–961.
https://doi.org/10.1158/2326-6066.CIR-22-0017
Published: 03 August 2022
View articletitled, Activation of Tumor-Cell STING Primes NK-Cell Therapy
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Includes: Supplementary data
Journal Articles

Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance

Free
Livnat Jerby, Parin Shah, Michael S. Cuoco, Christopher Rodman, Mei-Ju Su, Johannes M. Melms, Rachel Leeson, Abhay Kanodia, Shaolin Mei, Jia-Ren Lin, Shu Wang, Bokang Rabasha, David Liu, Gao Zhang, Claire Margolais, Orr Ashenberg, Patrick A. Ott, Elizabeth I. Buchbinder, Riz Haq, Stephen Hodi, Genevieve M. Boland, Ryan J. Sullivan, Dennie Frederick, Benchun Miao, Tabea Moll, Keith Flaherty, Meenhard Herlyn, Russell S. Jenkins, Rohit Thummalapalli, Monika S. Kowalczyk, Israel Canadas, Bastian Schilling, Adam N.R Cartwright, Adrienne M. Luoma, Shruti Malu, Patrick Hwu, Chantale Bernatchez, Marie-Andree Forget, David A. Barbie, Alex K. Shalek, Itay Tirosh, Peter K. Sorger, Kai W. Wucherpfennig, Eliezer M. Van Allen, Dirk Schadendorf, Bruce E. Johnson, Asaf Rotem, Orit Rosenblatt-Rozen, Levi A. Garraway, Charles H. Yoon, Benjamin Izar, Aviv Regev
Journal: Cancer Immunology Research
Cancer Immunol Res (2019) 7 (2_Supplement): A082.
https://doi.org/10.1158/2326-6074.CRICIMTEATIAACR18-A082
Published: 01 February 2019
View articletitled, Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance
Journal Articles

A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing

Free
Patrick H. Lizotte, Ruey-Long Hong, Troy A. Luster, Megan E. Cavanaugh, Luke J. Taus, Stephen Wang, Abha Dhaneshwar, Naomi Mayman, Aaron Yang, Meghana Kulkarni, Lauren Badalucco, Erica Fitzpatrick, Hsiang-Fong Kao, Mari Kuraguchi, Mark Bittinger, Paul T. Kirschmeier, Nathanael S. Gray, David A. Barbie, Pasi A. Jänne
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2018) 6 (12): 1511–1523.
https://doi.org/10.1158/2326-6066.CIR-18-0193
Published: 03 December 2018
View articletitled, A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing
Open the PDF for A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing in another window
Includes: Supplementary data
Journal Articles

Cytotoxic T Cells in PD-L1–Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors

Free
Mark M. Awad, Robert E. Jones, Hongye Liu, Patrick H. Lizotte, Elena V. Ivanova, Meghana Kulkarni, Grit S. Herter-Sprie, Xiaoyun Liao, Abigail A. Santos, Mark A. Bittinger, Lauren Keogh, Shohei Koyama, Christina Almonte, Jessie M. English, Julianne Barlow, William G. Richards, David A. Barbie, Adam J. Bass, Scott J. Rodig, F. Stephen Hodi, Kai W. Wucherpfennig, Pasi A. Jänne, Lynette M. Sholl, Peter S. Hammerman, Kwok-Kin Wong, Raphael Bueno
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (12): 1038–1048.
https://doi.org/10.1158/2326-6066.CIR-16-0171
Published: 30 November 2016
View articletitled, Cytotoxic T Cells in PD-L1–Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors
Open the PDF for Cytotoxic T Cells in PD-L1–Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors in another window
Includes: Supplementary data
Journal Articles

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

Free
Shenghong Yang, Yu Imamura, Russell W. Jenkins, Israel Cañadas, Shunsuke Kitajima, Amir Aref, Arthur Brannon, Eiji Oki, Adam Castoreno, Zehua Zhu, Tran Thai, Jacob Reibel, Zhirong Qian, Shuji Ogino, Kwok K. Wong, Hideo Baba, Alec C. Kimmelman, Marina Pasca Di Magliano, David A. Barbie
Journal: Cancer Immunology Research
Cancer Immunol Res (2016) 4 (6): 520–530.
https://doi.org/10.1158/2326-6066.CIR-15-0235
Published: 31 May 2016
View articletitled, Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation
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Includes: Supplementary data
Journal Articles

Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation

Free
Eliezer M. Van Allen, Hadrien G. Golay, Yan Liu, Shohei Koyama, Karrie Wong, Amaro Taylor-Weiner, Marios Giannakis, Maegan Harden, Vanesa Rojas-Rudilla, Aaron Chevalier, Tran Thai, Christine Lydon, Stacy Mach, Ada G. Avila, Joshua A. Wong, Alexandra R. Rabin, Joshua Helmkamp, Lynette Sholl, Scott L. Carter, Geoffrey Oxnard, Pasi Janne, Gad Getz, Neal Lindeman, Peter S. Hammerman, Levi A. Garraway, F. Stephen Hodi, Scott J. Rodig, Glenn Dranoff, Kwok-Kin Wong, David A. Barbie
Journal: Cancer Immunology Research
Series: Author Choice
Cancer Immunol Res (2015) 3 (8): 855–863.
https://doi.org/10.1158/2326-6066.CIR-15-0024
Published: 03 August 2015
View articletitled, Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation
Open the PDF for Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation in another window
Includes: Supplementary data