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Christopher J. Nirschl
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Journal Articles

mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity

Open Access
Christopher J. Nirschl, Heather R. Brodkin, Celesztina Domonkos, Connor J. Dwyer, Daniel J. Hicklin, Nesreen Ismail, Cynthia Seidel-Dugan, Philipp Steiner, Zoe Steuert, Jenna M. Sullivan, William M. Winston, Andres Salmeron
Journal: Cancer Immunology Research
Cancer Immunol Res (2023) 11 (7): 962–977.
https://doi.org/10.1158/2326-6066.CIR-22-0705
Published: 05 July 2023
View articletitled, mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity
Open the PDF for mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity in another window
Includes: Supplementary data
Journal Articles

Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression

Open Access
Christopher J. Nirschl, Heather R. Brodkin, Daniel J. Hicklin, Nesreen Ismail, Kristin Morris, Cynthia Seidel-Dugan, Philipp Steiner, Zoe Steuert, Jenna M. Sullivan, Ethika Tyagi, William M. Winston, Andres Salmeron
Journal: Cancer Immunology Research
Cancer Immunol Res (2022) 10 (5): 581–596.
https://doi.org/10.1158/2326-6066.CIR-21-0831
Published: 03 May 2022
View articletitled, Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression
Open the PDF for Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression in another window
Includes: Supplementary data
Journal Articles

PPARγ Contributes to Immunity Induced by Cancer Cell Vaccines That Secrete GM-CSF

Available to Purchase
Girija Goyal, Karrie Wong, Christopher J. Nirschl, Nicholas Souders, Donna Neuberg, Niroshana Anandasabapathy, Glenn Dranoff
Journal: Cancer Immunology Research
Cancer Immunol Res (2018) 6 (6): 723–732.
https://doi.org/10.1158/2326-6066.CIR-17-0612
Published: 31 May 2018
View articletitled, PPARγ Contributes to Immunity Induced by Cancer Cell Vaccines That Secrete GM-CSF
Open the PDF for PPARγ Contributes to Immunity Induced by Cancer Cell Vaccines That Secrete GM-CSF in another window
Includes: Supplementary data
Journal Articles

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1–Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

Available to Purchase
Andrew B. Sharabi, Christopher J. Nirschl, Christina M. Kochel, Thomas R. Nirschl, Brian J. Francica, Esteban Velarde, Theodore L. Deweese, Charles G. Drake
Journal: Cancer Immunology Research
Cancer Immunol Res (2015) 3 (4): 345–355.
https://doi.org/10.1158/2326-6066.CIR-14-0196
Published: 05 April 2015
View articletitled, Stereotactic Radiation Therapy Augments Antigen-Specific PD-1–Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen
Open the PDF for Stereotactic Radiation Therapy Augments Antigen-Specific PD-1–Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen in another window
Includes: Supplementary data